CAPZB, capping actin protein of muscle Z-line subunit beta

CAPZB, capping actin protein of muscle Z-line subunit beta

• This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

• Gene Synonyms (F-actin-capping protein subunit beta, capZ beta, capping actin protein of muscle Z-line beta subunit, capping protein (actin filament) muscle Z-line, beta, epididymis secretory sperm binding protein, CAPB, CAPPB, CAPZ,)
• NCBI Gene ID: 832
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P47756
  UNIPROT ID#>>B4DWA6
  UNIPROT ID#>>Q7L4N0
  UNIPROT ID#>>B1AK85
  UNIPROT ID#>>B1AK88
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

capping actin protein of muscle Z-line subunit beta interacts with:

• 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  5'-3' exoribonuclease 2
  AAR2 splicing factor
  actin related protein 1B
  actin related protein 2/3 complex subunit 2
  actin related protein 2/3 complex subunit 3
  actin related protein 2/3 complex subunit 5
  actin related protein 2/3 complex subunit 5 like
  actin, beta
  AKT serine/threonine kinase 3
  anillin actin binding protein
  anoctamin 7
  anterior gradient 2, protein disulphide isomerase family member
  ARP1 actin-related protein 1B, centractin beta
  B cell linker
  BAG cochaperone 3
  BICD cargo adaptor 2
  BRCA2 and CDKN1A interacting protein
  cadherin 1
  calmodulin-like 3
  capping protein regulator and myosin 1 linker 1
  catenin beta like 1
  CCR4-NOT transcription complex subunit 1
  CCR4-NOT transcription complex subunit 2
  CD2 associated protein
  CD2-associated protein
  cell division cycle 73
  centrosomal protein 152
  centrosomal protein 295
  CF transmembrane conductance regulator
  coiled-coil domain containing 8
  coronin, actin binding protein 1C
  cullin 7
  cyclin dependent kinase 2
  cyclin dependent kinase 9
  cyclin G associated kinase
  CYLD lysine 63 deubiquitinase
  cytochrome c oxidase assembly homolog COX15
  dCTP pyrophosphatase 1
  DDB1 and CUL4 associated factor 15
  DDB1 and CUL4 associated factor 4
  DEAD-box helicase 53
  death associated protein kinase 1
  DExD-box helicase 39B
  dihydrolipoamide dehydrogenase
  DISC1 scaffold protein
  DM1 locus, WD repeat containing
  drebrin 1
  dual specificity phosphatase 8
  dual specificity tyrosine phosphorylation regulated kinase 1A
  dynactin 1
  dynactin 2
  dynactin 3
  dynactin 4
  dynactin 5
  dynactin subunit 1
  dynactin subunit 2
  dynactin subunit 4
  dynactin subunit 6
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  estrogen receptor 1
  estrogen receptor 2
  eukaryotic translation initiation factor 4A3
  FA complementation group D2
  F-box protein 6
  fibronectin 1
  filamin A
  filamin, beta
  flotillin 1
  GLI family zinc finger 1
  H2B clustered histone 3
  heat shock protein family A (Hsp70) member 8
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  hexosaminidase subunit alpha
  hook microtubule tethering protein 3
  integrin alpha 5 (fibronectin receptor alpha)
  integrin subunit alpha 4
  IQ motif containing GTPase activating protein 1
  junction plakoglobin
  KRAS proto-oncogene, GTPase
  La ribonucleoprotein 7, transcriptional regulator
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucine rich repeat kinase 2
  LIM domain and actin binding 1
  LIM domain and actin binding 1
  mago homolog, exon junction complex subunit
  mediator of DNA damage checkpoint 1
  membrane bound transcription factor peptidase, site 2
  methylphosphate capping enzyme
  microtubule affinity regulating kinase 2
  microtubule affinity regulating kinase 3
  minichromosome maintenance complex component 2
  mitochondrial ribosomal protein L20
  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 11
  myosin heavy chain 9
  myosin IC
  myosin VB
  myosin VC
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  myotrophin
  neurotrophic receptor tyrosine kinase 1
  ninein
  NSF attachment protein alpha
  nuclear transcription factor, X-box binding 1
  obscurin like cytoskeletal adaptor 1
  palmitoyl-protein thioesterase 1
  PAX interacting protein 1
  PCI domain containing 2
  PDZ and LIM domain 7
  PIH1 domain containing 1
  platelet activating factor acetylhydrolase 1b regulatory subunit 1
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing O1
  pleckstrin homology domain containing O2
  pleiotrophin
  poly(A) specific ribonuclease subunit PAN2
  proteasome 26S subunit, ATPase 1
  proteasome activator subunit 3
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 2 regulatory subunit Bbeta
  RAD18 E3 ubiquitin protein ligase
  RCSD domain containing 1
  RecQ like helicase 4
  Rho GTPase activating protein 17
  ribonuclease P/MRP subunit p14
  ribosomal protein L36a
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 138
  ring finger protein 169
  RNA polymerase II associated protein 3
  RPGRIP1 like
  scavenger receptor class B member 2
  serine/threonine/tyrosine interacting protein
  SH3 domain containing kinase binding protein 1
  signal regulatory protein alpha
  signal transducing adaptor family member 1
  sirtuin 6
  solute carrier family 25 member 1
  Sp1 transcription factor
  SRY-box transcription factor 2
  synaptopodin
  tankyrase 1 binding protein 1
  TATA-box binding protein associated factor 2
  testin LIM domain protein
  translocase of outer mitochondrial membrane 40
  tripartite motif containing 14
  tripartite motif containing 25
  tripartite motif-containing 59
  tropomodulin 3
  tropomodulin 3
  tropomyosin 1, alpha
  tropomyosin 2
  tubulin beta 3 class III
  tumor protein p53
  tumor protein p53 binding protein 1
  twinfilin actin binding protein 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 Q2
  ubiquitin interaction motif containing 1
  ubiquitin like 7
  ubiquitin like modifier activating enzyme 2
  ubiquitin specific peptidase 14
  vacuole membrane protein 1
  valosin containing protein
  vascular cell adhesion molecule 1
  vinculin
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  VPS26, retromer complex component A
  WASH complex subunit 1
  WASH complex subunit 2C
  WW domain containing E3 ubiquitin protein ligase 2
  Yes1 associated transcriptional regulator
  zinc finger protein 574

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.