MARK2, microtubule affinity regulating kinase 2

MARK2, microtubule affinity regulating kinase 2

• This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

• Gene Synonyms (EMK-1, EMK1, PAR-1, Par-1b, Par1b, serine/threonine-protein kinase MARK2, ELKL motif kinase 1, MAP/microtubule affinity-regulating kinase 2, PAR1 homolog b, Ser/Thr protein kinase PAR-1B, serine/threonine protein kinase EMK, testicular tissue protein Li 117,)
• NCBI Gene ID: 2011
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K2S4
  UNIPROT ID#>>A0A140VJP1
  UNIPROT ID#>>Q7KZI7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

microtubule affinity regulating kinase 2 interacts with:

• alpha-L-fucosidase 1
  aurora kinase B
  autophagy related 16 like 1
  BAR/IMD domain containing adaptor protein 2
  cadherin 19
  calcium/calmodulin dependent protein kinase I
  calcium/calmodulin dependent serine protein kinase
  calmodulin regulated spectrin associated protein family member 2
  cell division cycle 14A
  centromere protein E
  centrosomal protein 57
  centrosomal protein 85 like
  centrosomal protein 89
  ceramide transporter 1
  chibby family member 1, beta catenin antagonist
  chromosome 11 open reading frame 58
  coiled-coil domain containing 8
  coiled-coil domain containing 82
  CREB regulated transcription coactivator 2
  cyclin dependent kinase 15
  cytoplasmic linker associated protein 1
  cytoplasmic linker associated protein 2
  discs large MAGUK scaffold protein 5
  discs large MAGUK scaffold protein 5
  estrogen receptor 2
  F-box and leucine rich repeat protein 16
  F-box protein 7
  FRY like transcription coactivator
  G protein-coupled receptor associated sorting protein 1
  glycogen synthase kinase 3 alpha
  glycogen synthase kinase 3 beta
  GRB2 associated binding protein 1
  GRB2 associated binding protein 2
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  heterogeneous nuclear ribonucleoprotein A1
  histone deacetylase 4
  histone deacetylase 7
  HRas proto-oncogene, GTPase
  kinesin associated protein 3
  kinesin family member 13B
  kinesin family member 5B
  KRAS proto-oncogene, GTPase
  lactate dehydrogenase D
  lysosomal associated membrane protein 1
  MANSC domain containing 1
  microtubule affinity regulating kinase 1
  microtubule affinity regulating kinase 2
  microtubule affinity regulating kinase 3
  microtubule affinity regulating kinase 4
  microtubule associated protein tau
  microtubule crosslinking factor 1
  mitogen-activated protein kinase kinase kinase 3
  NEDD4 E3 ubiquitin protein ligase
  NEDD4 like E3 ubiquitin protein ligase
  negative regulator of reactive oxygen species
  neurotrophic receptor tyrosine kinase 1
  NRAS proto-oncogene, GTPase
  NUAK family kinase 2
  nucleoporin 42
  nucleosome assembly protein 1 like 5
  par-3 family cell polarity regulator
  par-3 family cell polarity regulator beta
  par-6 family cell polarity regulator alpha
  par-6 family cell polarity regulator gamma
  peptidase, mitochondrial processing subunit alpha
  peroxiredoxin 3
  PH domain and leucine rich repeat protein phosphatase 1
  pleckstrin homology domain containing A4
  polycystin 1, transient receptor potential channel interacting
  programmed cell death 7
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase C epsilon
  protein kinase C iota
  protein phosphatase 2 phosphatase activator
  protein phosphatase 2 regulatory subunit B'epsilon
  protein phosphatase 2 scaffold subunit Aalpha
  protein tyrosine phosphatase receptor type D
  PTEN induced kinase 1
  RAB11 family interacting protein 2
  remodeling and spacing factor 1
  replication protein A2
  Rho/Rac guanine nucleotide exchange factor 2
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 41
  serine/threonine kinase 11
  serine/threonine kinase 3
  serine/threonine kinase 4
  SIX homeobox 2
  SMAD specific E3 ubiquitin protein ligase 1
  stratifin
  suppressor of glucose, autophagy associated 1
  suppressor of glucose, autophagy associated 1
  syntrophin beta 2
  transcriptional adaptor 2A
  transmembrane and coiled-coil domain family 2
  transmembrane protein 17
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin specific peptidase 21
  UTP18 small subunit processome component
  utrophin
  valosin containing protein
  vir like m6A methyltransferase associated
  WD repeat domain 46

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.