CASP5, caspase 5

CASP5, caspase 5

• This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

• Gene Synonyms (caspase-5, TY protease, caspase 5, apoptosis-related cysteine peptidase, caspase 5, apoptosis-related cysteine protease, protease ICH-3, protease TY, ICE(rel)III, ICEREL-III, ICH-3,)
• NCBI Gene ID: 838
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51878
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

caspase 5 interacts with:

• caspase 5
  C-terminal Src kinase
  lacritin
  MYC associated factor X
  NLR family pyrin domain containing 1
  periphilin 1
  Rho GTPase activating protein 44

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.