KYAT1, kynurenine aminotransferase 1

KYAT1, kynurenine aminotransferase 1

• This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (kynurenine--oxoglutarate transaminase 1, beta-lysase, kidney, cysteine conjugate beta lyase 1, cysteine conjugate-beta lyase, cytoplasmic, cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase), cysteine-S-conjugate beta-lyase, glutamine transaminase K, glutamine--phenylpyruvate transaminase, glutamine-phenylpyruvate aminotransferase, kyneurenine aminotransferase, kynurenine aminotransferase I, kynurenine--oxoglutarate transaminase I, CCBL1, GTK, KAT1, KATI,)
• NCBI Gene ID: 883
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16773
  UNIPROT ID#>>A8K563
  UNIPROT ID#>>B7Z4W5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

kynurenine aminotransferase 1 interacts with:

• diacylglycerol kinase theta
  kynurenine aminotransferase 1
  MAP3K12 binding inhibitory protein 1
  nuclear RNA export factor 1
  selenocysteine lyase
  serine hydroxymethyltransferase 2
  thyroid hormone receptor interactor 13
  VAC14 component of PIKFYVE complex
  YEATS domain containing 2
  zinc finger protein 318
  zinc finger ZZ-type containing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.