CENPE, centromere protein E

CENPE, centromere protein E

• Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]

• Gene Synonyms (centromere-associated protein E, Centromere autoantigen E (312kD), centromere protein E, 312kDa, kinesin family member 10, kinesin-7, kinesin-related protein CENPE, protein phosphatase 1, regulatory subunit 61, CENP-E, KIF10, MCPH13, PPP1R61,)
• NCBI Gene ID: 1062
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q02224
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

centromere protein E interacts with:

• beaded filament structural protein 2
  BICD cargo adaptor 2
  CDC like kinase 1
  centromere protein E
  centromere protein E
  centromere protein F
  centrosomal protein 131
  chromobox 2
  chromobox 4
  cullin 1
  cytoplasmic linker associated protein 2
  DnaJ heat shock protein family (Hsp40) member B1
  dynein cytoplasmic 1 intermediate chain 2
  FA complementation group A
  leucine rich pentatricopeptide repeat containing
  Max protein
  mitochondrial ribosomal protein L24
  mitogen-activated protein kinase 1
  mitotic spindle positioning
  NFKB activating protein
  ninein
  ninein like
  NUF2 component of NDC80 kinetochore complex
  OFD1 centriole and centriolar satellite protein
  pericentriolar material 1
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 7
  protein regulator of cytokinesis 1
  ribonucleic acid export 1
  ring finger protein 123
  spectrin alpha, non-erythrocytic 1
  S-phase kinase associated protein 1
  supervillin
  suppressor of cytokine signaling 6
  synaptonemal complex central element protein 3
  synaptopodin
  TNF receptor associated factor 4
  translin
  tropomyosin 4
  tumor protein p63
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  ubiquitin C
  ubiquitin specific peptidase 11
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.