CYBA, cytochrome b-245 alpha chain

CYBA, cytochrome b-245 alpha chain

• Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]

• Gene Synonyms (cytochrome b-245 light chain, cytochrome b light chain, cytochrome b(558) alpha chain, cytochrome b(558) alpha-subunit, cytochrome b, alpha polypeptide, cytochrome b-245, alpha polypeptide, cytochrome b558 subunit alpha, flavocytochrome b-558 alpha polypeptide, neutrophil cytochrome b 22 kDa polypeptide, p22 phagocyte B-cytochrome, p22phox, superoxide-generating NADPH oxidase light chain subunit, CGD4, p22-PHOX,)
• NCBI Gene ID: 1535
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P13498
  UNIPROT ID#>>H3BNP7
  UNIPROT ID#>>B4DT46
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cytochrome b-245 alpha chain interacts with:

• amyloid beta precursor protein binding protein 2
  B cell receptor associated protein 31
  cytochrome b-245 beta chain
  MyoD family inhibitor
  NADPH oxidase 1
  neutrophil cytosolic factor 1
  neutrophil cytosolic factor 2
  neutrophil cytosolic factor 4
  proteasome 20S subunit alpha 3
  Rac family small GTPase 1
  riboflavin kinase
  ring finger and CHY zinc finger domain containing 1
  RNA binding protein, mRNA processing factor
  solute carrier family 2 member 12
  TNF receptor superfamily member 1A
  UPF2 regulator of nonsense mediated mRNA decay
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  wolframin ER transmembrane glycoprotein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.