DFFA, DNA fragmentation factor subunit alpha

DFFA, DNA fragmentation factor subunit alpha

• Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DNA fragmentation factor subunit alpha, DFF45, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor, 45kDa, alpha polypeptide, inhibitor of CAD, DFF-45, DFF1, ICAD,)
• NCBI Gene ID: 1676
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R4H5
  UNIPROT ID#>>O00273
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DNA fragmentation factor subunit alpha interacts with:

• autophagy related 3
  basic leucine zipper and W2 domains 2
  CCHC-type zinc finger nucleic acid binding protein
  cell death inducing DFFA like effector b
  DNA fragmentation factor subunit beta
  dual specificity phosphatase 12
  egl-9 family hypoxia inducible factor 3
  eukaryotic translation initiation factor 5
  eukaryotic translation initiation factor 6
  EWS RNA binding protein 1
  fermitin family member 2
  G protein subunit beta 4
  glyceraldehyde-3-phosphate dehydrogenase
  granzyme B
  granzyme M
  heat shock protein family B (small) member 1
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  isochorismatase domain containing 1
  leucine rich repeat kinase 2
  MCC regulator of WNT signaling pathway
  methionine adenosyltransferase 2A
  methionine adenosyltransferase 2B
  Mov10 RISC complex RNA helicase
  neurotrophic receptor tyrosine kinase 1
  N-terminal EF-hand calcium binding protein 2
  nuclear RNA export factor 1
  nucleosome assembly protein 1 like 5
  phosphoribosylformylglycinamidine synthase
  protein kinase AMP-activated catalytic subunit alpha 2
  protein phosphatase 5 catalytic subunit
  ribosomal protein S6 kinase A3
  septin 5
  striatin 4
  target of myb1 like 2 membrane trafficking protein
  transmembrane BAX inhibitor motif containing 4
  TSPY like 4
  tubulin alpha 1a
  tubulin beta class I
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin specific peptidase 15

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.