GZMB, granzyme B

GZMB, granzyme B

• This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]

• Gene Synonyms (granzyme B, T-cell serine protease 1-3E, cathepsin G-like 1, cytotoxic T-lymphocyte proteinase 2, cytotoxic serine protease B, fragmentin 2, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), human lymphocyte protein, C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT,)
• NCBI Gene ID: 3002
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q67BC3
  UNIPROT ID#>>P10144
  UNIPROT ID#>>Q6XGZ4
  UNIPROT ID#>>J3KQ52
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

granzyme B interacts with:

• BH3 interacting domain death agonist
  bromodomain and PHD finger containing, 1
  c-abl oncogene 1, non-receptor tyrosine kinase
  caspase 3
  caspase 7
  CD2 associated protein
  CD2-associated protein
  fibroblast growth factor receptor 1
  granzyme B
  heat shock protein 1B
  heat shock protein family A (Hsp70) member 4
  heterogeneous nuclear ribonucleoprotein H2
  insulin like growth factor 2 receptor
  intersectin 1 (SH3 domain protein 1A)
  lamin A/C
  lamin B1
  notch 1
  perforin 1
  poly(A) binding protein, cytoplasmic 1
  prostaglandin E synthase 3
  prostaglandin E synthase 3
  protein kinase, DNA-activated, catalytic subunit
  protein tyrosine kinase 2
  RAB27A, member RAS oncogene family
  serglycin
  serpin family B member 9
  tubulin alpha 1a
  tubulin, alpha 1A
  ubiquitination factor E4A
  ubiquitination factor E4B
  X-ray repair cross complementing 4
  X-ray repair cross complementing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.