PHC1, polyhomeotic homolog 1

PHC1, polyhomeotic homolog 1

• This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]

• Gene Synonyms (EDR1, HPH1, MCPH11, RAE28, polyhomeotic-like protein 1, early development regulator 1 (homolog of polyhomeotic 1), early development regulatory protein 1, polyhomeotic-like 1,)
• NCBI Gene ID: 1911
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P78364
  UNIPROT ID#>>Q6N083
  UNIPROT ID#>>Q6GMQ3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

polyhomeotic homolog 1 interacts with:

• Bmi1 polycomb ring finger oncogene
  chromobox 2
  chromobox 2
  chromobox 4
  chromobox 6
  chromobox 7
  chromobox 8
  COMMD3-BMI1 readthrough
  dpy-30 histone methyltransferase complex regulatory subunit
  ELAV like RNA binding protein 1
  embryonic ectoderm development
  family with sequence similarity 9 member A
  geminin DNA replication inhibitor
  H2B clustered histone 8
  heat shock protein family A (Hsp70) member 8
  histone deacetylase 2
  mediator of DNA damage checkpoint 1
  Nanog homeobox
  neuronal pentraxin receptor
  PAF1 homolog, Paf1/RNA polymerase II complex component
  polycomb group ring finger 2
  polycomb group ring finger 3
  polyhomeotic homolog 1
  polyhomeotic homolog 2
  polyhomeotic homolog 3
  protein inhibitor of activated STAT 2
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit gamma
  ring finger protein 1
  ring finger protein 1
  ring finger protein 2
  ring finger protein 4
  Scm like with four mbt domains 1
  Scm like with four mbt domains 2
  Scm polycomb group protein homolog 1
  Scm polycomb group protein like 1
  siah E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 1
  Snf2 related CREBBP activator protein
  SP100 nuclear antigen
  syndecan binding protein 2
  transient receptor potential cation channel subfamily M member 3
  tubulin alpha 1c
  ubiquitin conjugating enzyme E2 I
  zinc finger CCHC-type containing 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.