EGR1, early growth response 1

EGR1, early growth response 1

• The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

• Gene Synonyms (AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225, early growth response protein 1, EGR-1, nerve growth factor-induced protein A, transcription factor ETR103, transcription factor Zif268, zinc finger protein 225, zinc finger protein Krox-24,)
• NCBI Gene ID: 1958
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P18146
  UNIPROT ID#>>Q546S1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

early growth response 1 interacts with:

• AT-rich interaction domain 2
  cell death inducing DFFA like effector c
  cereblon
  DNA methyltransferase 3 like
  DnaJ heat shock protein family (Hsp40) member C8
  E1A binding protein p300
  erb-b2 receptor tyrosine kinase 3
  FOS like 2, AP-1 transcription factor subunit
  growth arrest and DNA damage inducible beta
  interleukin 1 beta
  Jun proto-oncogene, AP-1 transcription factor subunit
  JunB proto-oncogene, AP-1 transcription factor subunit
  JunD proto-oncogene, AP-1 transcription factor subunit
  MAGE family member B2
  MDM2 proto-oncogene
  mediator complex subunit 6
  metadherin
  midnolin
  nestin
  NGFI-A binding protein 1
  NGFI-A binding protein 2
  nuclear factor of activated T cells 1
  nuclear factor of activated T cells 2
  paired like homeodomain 1
  phosphatase and tensin homolog
  pleckstrin homology domain interacting protein
  POP1 homolog, ribonuclease P/MRP subunit
  prefoldin subunit 5
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, non-ATPase 2
  RELA proto-oncogene, NF-kB subunit
  snail family transcriptional repressor 1
  Sp1 transcription factor
  steroid receptor RNA activator 1
  sterol regulatory element binding transcription factor 2
  T-box transcription factor 2
  tumor protein p53
  tumor protein p53 binding protein 1
  WD repeat and FYVE domain containing 1
  WT1 transcription factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.