NAB2, NGFI-A binding protein 2

NAB2, NGFI-A binding protein 2

• This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (MADER, NGFI-A-binding protein 2, EGR1 binding protein 2, melanoma-associated delayed early response protein,)
• NCBI Gene ID: 4665
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15742
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NGFI-A binding protein 2 interacts with:

• ankyrin repeat domain 11
  cancer/testis antigen 1A
  catenin alpha 3
  cell division cycle 23
  chromobox 8
  chromosome 9 open reading frame 78
  coiled-coil alpha-helical rod protein 1
  coiled-coil domain containing 187
  coiled-coil domain containing 33
  coiled-coil domain containing 57
  CUE domain containing 2
  CWF19 like cell cycle control factor 2
  DiGeorge syndrome critical region gene 6
  DiGeorge syndrome critical region gene 6 like
  DNA polymerase delta 2, accessory subunit
  elongin A
  enkurin domain containing 1
  exocyst complex component 8
  family with sequence similarity 9 member A
  glutaminyl-tRNA synthetase 1
  golgin A6 family like 9
  GRIP and coiled-coil domain containing 1
  heat shock transcription factor 2 binding protein
  janus kinase and microtubule interacting protein 2
  keratin 40
  keratin associated protein 10-3
  keratin associated protein 10-8
  kinesin family member 9
  leukocyte receptor cluster member 1
  ligand of numb-protein X 1
  microspherule protein 1
  mitogen-activated protein kinase 3
  mortality factor 4 like 1
  mortality factor 4 like 2
  NADPH dependent diflavin oxidoreductase 1
  neural precursor cell expressed, developmentally down-regulated 9
  neurobeachin
  NGFI-A binding protein 2
  NME/NM23 family member 7
  notch 2 N-terminal like A
  N-terminal glutamine amidase 1
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  PHD finger protein 1
  phosphatase, orphan 2
  phosphoinositide-3-kinase regulatory subunit 3
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
  proteasome 20S subunit alpha 1
  protein kinase AMP-activated catalytic subunit alpha 2
  protein kinase AMP-activated non-catalytic subunit beta 2
  RAD50 interactor 1
  replication factor C subunit 5
  RNA binding protein, mRNA processing factor
  sodium channel modifier 1
  sorbin and SH3 domain containing 3
  SPG21 abhydrolase domain containing, maspardin
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
  talin 1
  testis specific 10
  testis specific 10 interacting protein
  tetratricopeptide repeat domain 19
  TGFB induced factor homeobox 2 like Y-linked
  TNF receptor associated factor 2
  TNFAIP3 interacting protein 1
  transcription elongation factor A N-terminal and central domain containing
  transcription elongation factor A2
  trichoplein keratin filament binding
  ubiquitin specific peptidase 2
  UTP14C small subunit processome component
  VHL binding protein 1
  zinc finger BED-type containing 8
  zinc finger matrin-type 2
  zinc finger MYND-type containing 12
  zinc finger MYND-type containing 19
  zinc finger protein 417

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.