ETV6, ETS variant transcription factor 6

ETV6, ETS variant transcription factor 6

• This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]

• Gene Synonyms (TEL, TEL/ABL, THC5, transcription factor ETV6, ETS translocation variant 6, ETS variant 6, ETS-related protein Tel1, TEL1 oncogene, ets variant gene 6 (TEL oncogene),)
• NCBI Gene ID: 2120
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P41212
  UNIPROT ID#>>A0A0S2Z3C9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ETS variant transcription factor 6 interacts with:

• adaptor related protein complex 1 subunit mu 1
  axin 1
  egl-9 family hypoxia inducible factor 3
  ETS variant transcription factor 6
  ETS variant transcription factor 7
  F-box and leucine rich repeat protein 6
  Fli-1 proto-oncogene, ETS transcription factor
  GRB2 associated binding protein 2
  growth factor receptor bound protein 2
  histone deacetylase 3
  histone deacetylase 6
  histone deacetylase 9
  interferon regulatory factor 8
  L3MBTL histone methyl-lysine binding protein 1
  lamin A/C
  LDL receptor related protein 5
  LDL receptor related protein 6
  lysine acetyltransferase 5
  mediator of DNA damage checkpoint 1
  nidogen 2
  NK2 homeobox 1
  N-terminal glutamine amidase 1
  nuclear factor of activated T cells 2
  nuclear receptor corepressor 1
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  platelet derived growth factor receptor beta
  SIN3 transcription regulator family member A
  SMAD specific E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 1
  S-phase kinase associated protein 1
  SRY-box transcription factor 2
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 3
  TNF receptor associated factor 2
  TNF receptor associated factor 3
  tumor protein p53 binding protein 1
  ubiquitin conjugating enzyme E2 I
  ubiquitin specific peptidase 7
  vir like m6A methyltransferase associated
  VPS26, retromer complex component B
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.