F2RL1, F2R like trypsin receptor 1

F2RL1, F2R like trypsin receptor 1

• This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]

• Gene Synonyms (GPR11, PAR2, proteinase-activated receptor 2, G-protein coupled receptor 11, coagulation factor II (thrombin) receptor-like 1, protease-activated receptor 2, thrombin receptor-like 1,)
• NCBI Gene ID: 2150
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P55085
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

F2R like trypsin receptor 1 interacts with:

• chromosome 19 open reading frame 25
  COP9 signalosome subunit 5
  DNA methyltransferase 3 like
  G protein-coupled receptor associated sorting protein 1
  gem nuclear organelle associated protein 4
  gem nuclear organelle associated protein 6
  hydroxysteroid dehydrogenase like 2
  integrator complex subunit 12
  lamin A/C
  Mov10 RISC complex RNA helicase
  plasminogen
  proteinase 3
  RAD50 interactor 1
  sarcolemma associated protein
  ST14 transmembrane serine protease matriptase
  zw10 kinetochore protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.