GART, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

GART, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

• The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• Gene Synonyms (AIRS, GARS, GARTF, PAIS, PGFT, PRGS, trifunctional purine biosynthetic protein adenosine-3, GAR transformylase, GARS-AIRS-GART, glycinamide ribonucleotide formyltransferase, glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase,)
• NCBI Gene ID: 2618
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P22102
  UNIPROT ID#>>Q59HH3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase interacts with:

• AAR2 splicing factor
  ADP ribosylation factor interacting protein 1
  anterior gradient 2, protein disulphide isomerase family member
  ataxin 3
  atlastin GTPase 3
  BCL2-associated athanogene 2
  bone morphogenetic protein receptor, type 1A
  calmodulin-like 3
  cilia and flagella associated protein 65
  coiled-coil domain containing 8
  cullin 3
  cullin 5
  cullin 7
  derlin 1
  DnaJ heat shock protein family (Hsp40) member C7
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation initiation factor 4H
  exportin 7
  Fas associated factor 1
  F-box protein 6
  glycogen synthase kinase 3 beta
  heat shock protein family A (Hsp70) member 4
  heterogeneous nuclear ribonucleoprotein A1
  HIRA interacting protein 3
  histone deacetylase 4
  huntingtin interacting protein 1 related
  inositol polyphosphate-5-phosphatase K
  karyopherin subunit alpha 2
  La ribonucleoprotein 7, transcriptional regulator
  lysine demethylase 3A
  lysine demethylase 6B
  minichromosome maintenance complex component 2
  MYC proto-oncogene, bHLH transcription factor
  myosin XIX
  myosin, heavy polypeptide 9, non-muscle
  nestin
  neurotrophic receptor tyrosine kinase 1
  N-myc downstream regulated 1
  nuclear cap binding protein subunit 1
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  paxillin
  peptidylprolyl isomerase A
  phenylalanyl-tRNA synthetase subunit beta
  phosphoribosyl pyrophosphate amidotransferase
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  phosphoribosylformylglycinamidine synthase
  phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  prohibitin
  protein kinase D2
  PTEN induced kinase 1
  quinoid dihydropteridine reductase
  RAN binding protein 3
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  ribonucleoprotein, PTB binding 1
  ribosomal protein L24
  Ro60, Y RNA binding protein
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  selenophosphate synthetase 1
  SET nuclear proto-oncogene
  signal transducer and activator of transcription 6
  sirtuin 7
  snail family transcriptional repressor 1
  splicing factor 1
  SPT5 homolog, DSIF elongation factor subunit
  staufen double-stranded RNA binding protein 1
  sterol O-acyltransferase 1
  switching B cell complex subunit SWAP70
  TatD DNase domain containing 1
  testis expressed 101
  TNF receptor associated factor 6
  transforming growth factor beta 1
  tryptophanyl-tRNA synthetase 1
  ubiquitin conjugating enzyme E2 M
  ubiquitin protein ligase E3A
  UDP-glucose pyrophosphorylase 2
  vir like m6A methyltransferase associated
  WW domain containing oxidoreductase
  zinc finger CCCH-type containing 7A
  zyxin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.