GH1, growth hormone 1

GH1, growth hormone 1

• The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]

• Gene Synonyms (GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B, IGHD2, hGH-N, somatotropin, growth hormone B5, pituitary growth hormone,)
• NCBI Gene ID: 2688
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B1A4G6
  UNIPROT ID#>>P01241
  UNIPROT ID#>>B1A4G7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

growth hormone 1 interacts with:

• BAG cochaperone 3
  growth hormone 1
  growth hormone receptor
  leukotriene A4 hydrolase
  prolactin receptor
  serine/threonine kinase receptor associated protein
  SHC adaptor protein 1
  triggering receptor expressed on myeloid cells 2
  zinc finger containing ubiquitin peptidase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.