GLP1R, glucagon like peptide 1 receptor

GLP1R, glucagon like peptide 1 receptor

• This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

• Gene Synonyms (glucagon-like peptide 1 receptor, GLP-1 receptor, GLP1 receptor, seven transmembrane helix receptor, GLP-1, GLP-1-R, GLP-1R,)
• NCBI Gene ID: 2740
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P43220
  UNIPROT ID#>>A0A142FHB8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glucagon like peptide 1 receptor interacts with:

• acyl-CoA synthetase family member 3
  adipocyte-related X-chromosome expressed sequence 1
  ADP ribosylation factor related protein 1
  ADP-dependent glucokinase
  ADP-ribosylation factor 1
  ADP-ribosylation factor-like 1
  alanyl-tRNA synthetase
  androgen induced 1
  aph-1 homolog A, gamma-secretase subunit
  aph1 homolog B, gamma secretase subunit
  archain 1
  ARFGEF family member 3
  ATPase 13A1
  ATPase H+ transporting accessory protein 2
  ATPase, Ca++ transporting, plasma membrane 1
  ATPase, H+ transporting, lysosomal accessory protein 2
  ATPase, H+ transporting, lysosomal V1 subunit H
  ATPase, Na+/K+ transporting, beta 1 polypeptide
  ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  ATP-binding cassette, sub-family D (ALD), member 3
  Berardinelli-Seip congenital lipodystrophy 2 (seipin)
  beta-2 microglobulin
  calcyclin binding protein
  CAP-Gly domain containing linker protein family member 4
  carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  cell cycle exit and neuronal differentiation 1
  chaperonin containing Tcp1, subunit 3 (gamma)
  chromosome 18 open reading frame 32
  chromosome 4 open reading frame 3
  chymotrypsin like elastase 3B
  cleft lip and palate associated transmembrane protein 1
  coatomer protein complex subunit alpha
  coatomer protein complex, subunit beta 1
  coatomer protein complex, subunit beta 2 (beta prime)
  coatomer protein complex, subunit gamma 1
  coiled-coil domain containing 167
  complement factor I
  cornichon family AMPA receptor auxiliary protein 4
  cullin associated and neddylation disassociated 1
  cullin associated and neddylation dissociated 2 (putative)
  cyclin G associated kinase
  cysteine rich tail 1
  cysteine rich transmembrane module containing 1
  cytochrome b, mitochondrial
  cytochrome c oxidase II, mitochondrial
  dehydrogenase/reductase (SDR family) member 7
  dehydrogenase/reductase (SDR family) member 7B
  dehydrogenase/reductase 7
  diacylglycerol kinase, epsilon
  dolichol-phosphate (beta-D) mannosyltransferase 2
  EBP cholestenol delta-isomerase
  ELOVL fatty acid elongase 1
  emopamil binding protein-like
  endoplasmic reticulum protein 29
  enolase 1, alpha non-neuron
  ER membrane protein complex subunit 7
  ERGIC and golgi 3
  FK506 binding protein 11
  G protein-coupled receptor 108
  G protein-coupled receptor 37
  G protein-coupled receptor associated sorting protein 1
  gamma-aminobutyric acid type B receptor subunit 2
  gamma-glutamyltransferase 7
  glucose-6-phosphatase, catalytic, 2
  glucosidase, alpha, acid
  glutamate ionotropic receptor NMDA type subunit associated protein 1
  glutamine fructose-6-phosphate transaminase 1
  glycerophosphodiester phosphodiesterase domain containing 1
  glycoprotein 2
  GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
  GNAS complex locus
  guanine nucleotide binding protein (G protein), alpha inhibiting 2
  guanine nucleotide binding protein (G protein), alpha inhibiting 3
  guanine nucleotide binding protein (G protein), beta 1
  guanine nucleotide binding protein (G protein), gamma 12
  guanine nucleotide binding protein, alpha O
  hepcidin antimicrobial peptide
  hepsin
  immediate early response 3
  interferon induced transmembrane protein 3
  keratin associated protein 10-3
  keratin associated protein 10-7
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 1-1
  keratin associated protein 1-3
  keratin associated protein 17-1
  keratin associated protein 5-9
  keratinocyte associated protein 2
  ketohexokinase
  leptin receptor overlapping transcript-like 1
  lymphocyte antigen 6 complex, locus E
  lysosomal protein transmembrane 4 alpha
  lysosomal-associated protein transmembrane 4A
  major facilitator superfamily domain containing 5
  membrane-spanning 4-domains, subfamily A, member 6D
  mitochondrial carrier 2
  mitochondrial ribosomal protein L22
  mitochondrially encoded ATP synthase 6
  mitochondrially encoded NADH 4L dehydrogenase
  myosin light chain 6
  NADH dehydrogenase 6, mitochondrial
  NBPF member 19
  N-ethylmaleimide sensitive fusion protein attachment protein alpha
  neurocalcin delta
  neurogranin
  neutral cholesterol ester hydrolase 1
  nicastrin
  notch 2 N-terminal like A
  nuclear casein kinase and cyclin dependent kinase substrate 1
  OCIA domain containing 2
  oligosaccharyltransferase complex subunit 4, non-catalytic
  peptidylglycine alpha-amidating monooxygenase
  peptidylprolyl isomerase B
  phenylalanyl-tRNA synthetase, alpha subunit
  phosphatidylinositol glycan anchor biosynthesis class G
  phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
  PRA1 domain family 2
  progesterone receptor membrane component 1
  progesterone receptor membrane component 1
  progesterone receptor membrane component 2
  progestin and adipoQ receptor family member 6
  prolyl 4-hydroxylase, transmembrane
  proprotein convertase subtilisin/kexin type 2
  proteasome 26S subunit, non-ATPase 8
  proteasome subunit alpha 7
  protein O-mannosyltransferase 2
  protein phosphatase 2, regulatory subunit A, alpha
  pyrroline-5-carboxylate reductase family, member 2
  RAB14, member RAS oncogene family
  RAB18, member RAS oncogene family
  RAB27A, member RAS oncogene family
  RAB34, member RAS oncogene family
  RAB5A, member RAS oncogene family
  RAB5B, member RAS oncogene family
  RAB5B, member RAS oncogene family
  RAB5C, member RAS oncogene family
  RAB5C, member RAS oncogene family
  RAB6B, member RAS oncogene family
  RAS-related protein 1a
  receptor accessory protein 5
  reticulon 3
  reticulon 4
  ribosomal protein L3
  ring finger protein 5
  RNA transcription, translation and transport factor
  SEC11 homolog C, signal peptidase complex subunit
  Sec61 beta subunit
  secretoglobin family 2A member 1
  selenoprotein K
  selenoprotein K
  sequestosome 1
  serine palmitoyltransferase small subunit A
  serine palmitoyltransferase, small subunit A
  serine protease 2
  serpin family A member 1
  serum amyloid A1
  small ubiquitin like modifier 1
  solute carrier family 15 member 4
  solute carrier family 2 (facilitated glucose transporter), member 5
  solute carrier family 27 (fatty acid transporter), member 4
  solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
  solute carrier family 35, member B1
  solute carrier family 39 (metal ion transporter), member 13
  solute carrier family 39 (zinc transporter), member 7
  stathmin 1
  stathmin 3
  stomatin like 2
  stress associated endoplasmic reticulum protein 1
  SV2 related protein
  synaptogyrin 3
  synaptogyrin 4
  synaptosomal-associated protein 25
  SYS1 golgi trafficking protein
  tetraspanin 13
  tetraspanin 2
  thioredoxin-related transmembrane protein 4
  transferrin receptor
  translocase of outer mitochondrial membrane 6
  translocating chain-associating membrane protein 1
  transmembrane 4 L six family member 4
  transmembrane 9 superfamily member 1
  transmembrane and coiled-coil domains 3
  transmembrane BAX inhibitor motif containing 4
  transmembrane BAX inhibitor motif containing 6
  transmembrane p24 trafficking protein 10
  transmembrane p24 trafficking protein 9
  transmembrane protein 147
  transmembrane protein 176B
  transmembrane protein 33
  transmembrane protein 65
  triosephosphate isomerase 1
  tripartite motif-containing 21
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin specific peptidase 9, X chromosome
  UDP glucuronosyltransferase family 1 member A9
  unconventional SNARE in the ER 1 homolog (S. cerevisiae)
  uridine monophosphate synthetase
  USO1 vesicle docking factor
  VAMP associated protein B and C
  vesicle-associated membrane protein 3
  vesicle-associated membrane protein, associated protein A
  vesicle-associated membrane protein, associated protein B and C
  voltage-dependent anion channel 1
  Yip1 interacting factor homolog B (S. cerevisiae)
  zinc finger protein 99

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.