GMDS, GDP-mannose 4,6-dehydratase

GMDS, GDP-mannose 4,6-dehydratase

• GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]

• Gene Synonyms (GDP-mannose 4,6 dehydratase, GDP-D-mannose dehydratase, short chain dehydrogenase/reductase family 3E, member 1, GMD, SDR3E1,)
• NCBI Gene ID: 2762
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60547
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GDP-mannose 4,6-dehydratase interacts with:

• AAR2 splicing factor
  BAG cochaperone 3
  coiled-coil domain containing 22
  damage specific DNA binding protein 1
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  F-box and WD repeat domain containing 7
  GDP-mannose 4,6-dehydratase
  hypoxia inducible factor 1 subunit alpha inhibitor
  kinesin family member 2A
  methionine adenosyltransferase 2B
  NADH:ubiquinone oxidoreductase subunit A9
  nephrocystin 3
  neurofibromin 2
  NSFL1 cofactor
  N-terminal glutamine amidase 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  potassium voltage-gated channel subfamily A regulatory beta subunit 3
  proteasome assembly chaperone 4
  prothymosin alpha
  RAB2A, member RAS oncogene family
  RAB5C, member RAS oncogene family
  Rap1 GTPase-GDP dissociation stimulator 1
  ring finger protein 166
  ring-box 1
  Shoc2, leucine rich repeat scaffold protein
  SMAD family member 3
  spindle and kinetochore associated complex subunit 1
  tankyrase
  tankyrase 2
  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
  TatD DNase domain containing 1
  tetratricopeptide repeat domain 5
  tripartite motif containing 14

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.