GNB3, G protein subunit beta 3

GNB3, G protein subunit beta 3

• Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

• Gene Synonyms (guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3, G protein, beta-3 subunit, GTP-binding regulatory protein beta-3 chain, guanine nucleotide binding protein (G protein), beta polypeptide 3, guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3, hypertension associated protein, transducin beta chain 3, CSNB1H,)
• NCBI Gene ID: 2784
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P16520
  UNIPROT ID#>>E9PCP0
  UNIPROT ID#>>F1T0G5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

G protein subunit beta 3 interacts with:

• cell death inducing DFFA like effector b
  cullin 4A
  G protein subunit beta 3
  G protein subunit gamma 10
  G protein subunit gamma 11
  G protein subunit gamma 12
  G protein subunit gamma 13
  G protein subunit gamma 2
  G protein subunit gamma 3
  G protein subunit gamma 4
  G protein subunit gamma 5
  G protein subunit gamma 7
  G protein subunit gamma 8
  G protein subunit gamma transducin 2
  phosducin like
  RASD family member 2
  regulator of calcineurin 2
  regulator of G protein signaling 6
  solute carrier family 36 member 3
  transforming growth factor beta receptor 1
  zinc finger protein 131

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.