GRM5, glutamate metabotropic receptor 5

GRM5, glutamate metabotropic receptor 5

• This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

• Gene Synonyms (metabotropic glutamate receptor 5, glutamate receptor, metabotropic 5, protein phosphatase 1, regulatory subunit 86, GPRC1E, MGLUR5, PPP1R86, mGlu5,)
• NCBI Gene ID: 2915
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K5P7
  UNIPROT ID#>>P41594
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glutamate metabotropic receptor 5 interacts with:

• centrosomal protein 104
  EvC ciliary complex subunit 2
  G protein-coupled receptor associated sorting protein 1
  glutamate metabotropic receptor 5
  homer scaffold protein 1
  homer scaffold protein 3
  protein kinase C alpha
  protein kinase C beta
  protein kinase C delta
  protein kinase C epsilon
  protein kinase C gamma
  protein kinase C theta
  protein kinase C zeta
  regulator of G protein signaling 12
  siah E3 ubiquitin protein ligase 1
  trafficking regulator and scaffold protein tamalin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.