ID2, inhibitor of DNA binding 2

ID2, inhibitor of DNA binding 2

• The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

• Gene Synonyms (DNA-binding protein inhibitor ID-2, DNA-binding protein inhibitor ID2, cell growth-inhibiting gene 8, class B basic helix-loop-helix protein 26, helix-loop-helix protein ID2, inhibitor of DNA binding 2, HLH protein, inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, inhibitor of differentiation 2, GIG8, ID2A, ID2H, bHLHb26,)
• NCBI Gene ID: 3398
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q53T66
  UNIPROT ID#>>Q02363
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

inhibitor of DNA binding 2 interacts with:

• achaete-scute family bHLH transcription factor 4
  afadin, adherens junction formation factor
  ankyrin repeat and SOCS box containing 4
  BCAR1 scaffold protein, Cas family member
  chromosome 1 open reading frame 131
  chromosome 22 open reading frame 39
  craniofacial development protein 1
  cytoplasmic linker associated protein 2
  DDB1 and CUL4 associated factor 4
  death inducer-obliterator 1
  dual specificity tyrosine phosphorylation regulated kinase 1B
  elongator acetyltransferase complex subunit 4
  elongin C
  enkurin domain containing 1
  FA complementation group L
  fibroblast growth factor receptor substrate 3
  fibronectin type III domain containing 11
  GDP-L-fucose synthase
  HDGF like 2
  inhibitor of DNA binding 2
  inhibitor of DNA binding 4, HLH protein
  interferon gamma inducible protein 16
  kelch like family member 20
  kinesin family member 20B
  ligand dependent nuclear receptor interacting factor 1
  lysine demethylase 1A
  mesogenin 1
  microtubule actin crosslinking factor 1
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase 8
  musculin
  myogenic differentiation 1
  myogenic factor 5
  myogenic factor 6
  myogenin
  neural precursor cell expressed, developmentally down-regulated 9
  nuclear receptor subfamily 0 group B member 2
  oligodendrocyte transcription factor 1
  oligodendrocyte transcription factor 2
  paired box 2
  paired box 5
  paired box 8
  PHD finger protein 3
  protein arginine methyltransferase 5
  protein arginine methyltransferase 6
  protein interacting with PRKCA 1
  protein phosphatase 1 catalytic subunit alpha
  RAB, member RAS oncogene family like 6
  Ras and Rab interactor 3
  ras homolog family member U
  RB transcriptional corepressor 1
  RB transcriptional corepressor like 1
  RB transcriptional corepressor like 2
  ring finger protein 113A
  RNA binding motif protein 27
  RNA binding motif protein 48
  SAFB like transcription modulator
  sequestosome 1
  serine/threonine kinase 38
  SIN3 transcription regulator family member A
  sterol regulatory element binding transcription factor 1
  suppressor of variegation 3-9 homolog 1
  suppressor of variegation 3-9 homolog 2
  tensin 2
  TNFAIP3 interacting protein 2
  transcription factor 12
  transcription factor 3
  transcription factor 4
  trichoplein keratin filament binding
  tubulin alpha 1b
  tubulin beta 4B class IVb
  tubulin beta class I
  ubiquitin conjugating enzyme E2 E1
  ubiquitin specific peptidase 1
  unc-119 lipid binding chaperone
  von Hippel-Lindau tumor suppressor
  WW domain binding protein 11
  YY1 transcription factor
  zinc finger CCCH-type and G-patch domain containing

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.