IFNAR2, interferon alpha and beta receptor subunit 2

IFNAR2, interferon alpha and beta receptor subunit 2

• The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]

• Gene Synonyms (interferon alpha/beta receptor 2, IFN-R-2, IFN-alpha/beta receptor 2, human interferon alpha/beta receptor, interferon (alpha, beta and omega) receptor 2, interferon alpha binding protein, interferon receptor, interferon-alpha/beta receptor beta chain, type I interferon receptor 2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45,)
• NCBI Gene ID: 3455
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P48551
  UNIPROT ID#>>Q9BUA0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interferon alpha and beta receptor subunit 2 interacts with:

• GRB2 related adaptor protein 2
  interferon alpha and beta receptor subunit 2
  interferon beta 1
  interferon regulatory factor 9
  Janus kinase 1
  protein kinase C beta
  protein phosphatase 1 regulatory subunit 3B
  receptor for activated C kinase 1
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 2
  signal transducer and activator of transcription 3
  tyrosine kinase 2
  ubiquitin specific peptidase 18

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.