IL2, interleukin 2

IL2, interleukin 2

• The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

• Gene Synonyms (interleukin-2, T cell growth factor, aldesleukin, involved in regulation of T-cell clonal expansion, IL-2, TCGF, lymphokine,)
• NCBI Gene ID: 3558
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q0GK43
  UNIPROT ID#>>P60568
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 2 interacts with:

• forkhead box K2
  interleukin 17A
  interleukin 2
  interleukin 2 receptor subunit alpha
  interleukin 2 receptor subunit beta
  interleukin 2 receptor subunit gamma
  KH-type splicing regulatory protein
  nerve growth factor receptor
  SHC adaptor protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.