PDX1, pancreatic and duodenal homeobox 1

PDX1, pancreatic and duodenal homeobox 1

• The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Aug 2017]

• Gene Synonyms (GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1, pancreas/duodenum homeobox protein 1, IPF-1, IUF-1, glucose-sensitive factor, insulin promoter factor 1, homeodomain transcription factor, insulin upstream factor 1, islet/duodenum homeobox-1, pancreatic-duodenal homeobox factor 1, somatostatin transcription factor 1, somatostatin-transactivating factor 1,)
• NCBI Gene ID: 3651
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P52945
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pancreatic and duodenal homeobox 1 interacts with:

• MAF bZIP transcription factor A
  neuronal differentiation 1
  pancreatic and duodenal homeobox 1
  PBX homeobox 1
  PDX1 C-terminal inhibiting factor 1
  protein kinase, DNA-activated, catalytic subunit
  solute carrier family 2 member 2
  speckle type BTB/POZ protein
  transcription factor 3
  X-ray repair cross complementing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.