ITGA3, integrin subunit alpha 3

ITGA3, integrin subunit alpha 3

• The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]

• Gene Synonyms (CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, integrin alpha-3, CD49 antigen-like family member C, alpha 3 subunit of VLA-3 receptor, antigen CD49C, antigen identified by monoclonal antibody J143, galactoprotein B3, integrin alpha 3, integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor), testicular tissue protein Li 96, testicular tissue protein Li 98, very late activation protein 3 receptor, alpha-3 subunit,)
• NCBI Gene ID: 3675
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJM0
  UNIPROT ID#>>P26006
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

integrin subunit alpha 3 interacts with:

• ADAM metallopeptidase domain 9
  CD82 molecule
  F-box protein 6
  galectin 8
  HPS5 biogenesis of lysosomal organelles complex 2 subunit 2
  integrin beta 1 (fibronectin receptor beta)
  integrin subunit alpha 3
  integrin subunit beta 1
  integrin subunit beta 4
  integrin subunit beta 5
  lysosomal associated membrane protein 1
  RAB interacting factor
  RAD18 E3 ubiquitin protein ligase
  ring finger protein 4
  secretoglobin family 1D member 1
  tetraspanin 4
  TIMP metallopeptidase inhibitor 2
  von Hippel-Lindau tumor suppressor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.