JARID2, jumonji and AT-rich interaction domain containing 2

JARID2, jumonji and AT-rich interaction domain containing 2

• This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]

• Gene Synonyms (JMJ, protein Jumonji, jumonji homolog, jumonji, AT rich interactive domain 2, jumonji-like protein, jumonji/ARID domain-containing protein 2,)
• NCBI Gene ID: 3720
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92833
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

jumonji and AT-rich interaction domain containing 2 interacts with:

• AE binding protein 2
  bromodomain containing 2
  CDC16 cell division cycle 16
  chaperonin containing TCP1 subunit 5
  cyclin-dependent kinase 1
  embryonic ectoderm development
  euchromatic histone lysine methyltransferase 1
  euchromatic histone lysine methyltransferase 2
  metal response element binding transcription factor 2
  Nanog homeobox
  natriuretic peptide A
  POU class 5 homeobox 1
  RB binding protein 4, chromatin remodeling factor
  RB binding protein 7, chromatin remodeling factor
  RE1 silencing transcription factor
  RNA polymerase II, I and III subunit H
  SET domain bifurcated histone lysine methyltransferase 1
  SLAIN motif family member 2
  SUZ12 polycomb repressive complex 2 subunit
  tubulin alpha 1c
  tubulin tyrosine ligase-like family, member 7
  vir like m6A methyltransferase associated
  VRK serine/threonine kinase 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.