- Gene Overview
- Interaction Network
- Sequence Verification
EPCAM, epithelial cell adhesion molecule
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This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
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Gene Synonyms (DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1, epithelial cell adhesion molecule, adenocarcinoma-associated antigen, cell surface glycoprotein Trop-1, epithelial glycoprotein 314, human epithelial glycoprotein-2, major gastrointestinal tumor-associated protein GA733-2, membrane component, chromosome 4, surface marker (35kD glycoprotein), trophoblast cell surface antigen 1, tumor-associated calcium signal transducer 1,)
- NCBI Gene ID:
4072
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>P16422
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
epithelial cell adhesion molecule interacts with:
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this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
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