MAP3K10, mitogen-activated protein kinase kinase kinase 10

MAP3K10, mitogen-activated protein kinase kinase kinase 10

• The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (MEKK10, MLK2, MST, mitogen-activated protein kinase kinase kinase 10, MKN28 derived nonreceptor_type serine/threonine kinase, MKN28 kinase, mixed lineage kinase 2, protein kinase MST,)
• NCBI Gene ID: 4294
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q02779
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase kinase 10 interacts with:

• connector enhancer of kinase suppressor of Ras 1
  COP9 signalosome subunit 2
  cytochrome P450 family 4 subfamily F member 12
  dynamin 1 like
  hepatocyte growth factor-regulated tyrosine kinase substrate
  kinesin associated protein 3
  kinesin family member 17
  kinesin family member 3A
  kinesin family member 3B
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 12
  mitogen-activated protein kinase 8 interacting protein 1
  mitogen-activated protein kinase 8 interacting protein 2
  mitogen-activated protein kinase 9
  mitogen-activated protein kinase kinase 4
  mitogen-activated protein kinase kinase 7
  mitogen-activated protein kinase kinase kinase 10
  mitogen-activated protein kinase kinase kinase 21
  neuronal differentiation 1
  phosphoinositide-3-kinase regulatory subunit 2
  prohibitin
  proopiomelanocortin
  protein kinase C zeta
  Rac family small GTPase 1
  Rac GTPase activating protein 1
  SH3 domain containing ring finger 1
  SMAD specific E3 ubiquitin protein ligase 1
  solute carrier family 5 member 5
  sphingosine kinase 2
  tryptase alpha/beta 1
  tubulin beta class I
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.