MNT, MAX network transcriptional repressor

MNT, MAX network transcriptional repressor

• The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

• Gene Synonyms (MAD6, MXD6, ROX, bHLHd3, lncRNA-HAL, max-binding protein MNT, MAX binding protein, MNT, MAX dimerization protein, Max-interacting protein, class D basic helix-loop-helix protein 3, myc antagonist MNT,)
• NCBI Gene ID: 4335
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99583
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MAX network transcriptional repressor interacts with:

• H4 clustered histone 1
  MAX dimerization protein 3
  MAX dimerization protein MLX
  MAX network transcriptional repressor
  Max protein
  metadherin
  mitotic arrest deficient 1 like 1
  MYC proto-oncogene, bHLH transcription factor
  NCK adaptor protein 2
  ring finger protein 4
  SIN3 transcription regulator family member A
  SRY-box transcription factor 4
  transcriptional regulator, SIN3A (yeast)
  tumor protein p63
  ubiquitin protein ligase E3A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.