ABCC1, ATP binding cassette subfamily C member 1

ABCC1, ATP binding cassette subfamily C member 1

• The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

• Gene Synonyms (ABC29, ABCC, DFNA77, GS-X, MRP, MRP1, multidrug resistance-associated protein 1, ATP-binding cassette transporter variant ABCC1delta-ex13, ATP-binding cassette transporter variant ABCC1delta-ex13&14, ATP-binding cassette transporter variant ABCC1delta-ex25, ATP-binding cassette transporter variant ABCC1delta-ex25&26, ATP-binding cassette, sub-family C (CFTR/MRP), member 1, LTC4 transporter, glutathione-S-conjugate-translocating ATPase ABCC1, leukotriene C(4) transporter,)
• NCBI Gene ID: 4363
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P33527
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ATP binding cassette subfamily C member 1 interacts with:

• ATP binding cassette subfamily C member 1
  ATPase H+ transporting V1 subunit F
  ATPase H+ transporting V1 subunit H
  CTD phosphatase subunit 1
  CTD small phosphatase like
  eukaryotic translation initiation factor 3 subunit C
  FKBP prolyl isomerase 8
  flotillin 1
  H4 clustered histone 1
  limb development membrane protein 1 like
  mitochondrial calcium uniporter
  mitochondrial ribosomal protein L17
  NADH:ubiquinone oxidoreductase complex assembly factor 3
  NADH:ubiquinone oxidoreductase subunit B9
  neurotrophic receptor tyrosine kinase 1
  NFS1 cysteine desulfurase
  NRAS proto-oncogene, GTPase
  nucleophosmin 1
  OTU deubiquitinase with linear linkage specificity like
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  pleckstrin homology domain containing A4
  poly(U) binding splicing factor 60
  potassium channel, subfamily K, member 1
  progesterone receptor membrane component 2
  programmed cell death 6 interacting protein
  prostaglandin E synthase 3
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, non-ATPase 2
  pyruvate dehydrogenase complex component X
  ribonucleoprotein, PTB binding 1
  ribosomal protein S7
  scaffold attachment factor B
  SEC63 homolog, protein translocation regulator
  solute carrier family 15 member 3
  stimulator of interferon response cGAMP interactor 1
  STT3 oligosaccharyltransferase complex catalytic subunit B
  SURF1 cytochrome c oxidase assembly factor
  syntaxin 4
  thioredoxin related transmembrane protein 2
  TNF receptor associated factor 3
  transmembrane and coiled-coil domains 1
  transmembrane protein 17
  transmembrane protein 33
  tripartite motif containing 25
  tropomodulin 2
  unc-93 homolog B1, TLR signaling regulator
  valosin containing protein
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  voltage dependent anion channel 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.