MTHFR, methylenetetrahydrofolate reductase

MTHFR, methylenetetrahydrofolate reductase

• The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009]

• Gene Synonyms (methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (NADPH), methylenetetrahydrofolate reductase (NAD(P)H),)
• NCBI Gene ID: 4524
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IU67
  UNIPROT ID#>>Q59GJ6
  UNIPROT ID#>>P42898
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

methylenetetrahydrofolate reductase interacts with:

• BCL2 like 11
  cell division cycle associated 8
  DNA cross-link repair 1C
  LSM8 homolog, U6 small nuclear RNA associated
  methylenetetrahydrofolate reductase
  NADPH oxidase 5
  potassium voltage-gated channel modifier subfamily V member 2
  pre-mRNA processing factor 31
  protocadherin beta 16
  Ras association domain family member 1
  RecQ like helicase 4
  spermatogenesis associated 19
  sphingomyelin phosphodiesterase 2
  tigger transposable element derived 6
  transmembrane protein 223
  vir like m6A methyltransferase associated
  zinc finger protein 263
  zinc finger protein 556

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.