MYD88, MYD88 innate immune signal transduction adaptor

MYD88, MYD88 innate immune signal transduction adaptor

• This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

• Gene Synonyms (IMD68, MYD88D, myeloid differentiation primary response protein MyD88, mutant myeloid differentiation primary response 88, myeloid differentiation primary response 88, myeloid differentiation primary response gene (88),)
• NCBI Gene ID: 4615
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0A0MST0
  UNIPROT ID#>>A0A0A0MS70
  UNIPROT ID#>>A0A0A0MSI9
  UNIPROT ID#>>Q99836
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MYD88 innate immune signal transduction adaptor interacts with:

• autophagy related 5
  B cell scaffold protein with ankyrin repeats 1
  CD93 molecule
  cytohesin 2
  Fas associated via death domain
  histone deacetylase 6
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  interleukin 1 receptor accessory protein
  interleukin 1 receptor associated kinase 3
  interleukin 1 receptor associated kinase 4
  interleukin 1 receptor like 1
  LRR binding FLII interacting protein 1
  LRR binding FLII interacting protein 2
  MAP3K12 binding inhibitory protein 1
  mitogen-activated protein kinase kinase kinase 7
  MYD88 innate immune signal transduction adaptor
  N-terminal glutamine amidase 1
  pellino E3 ubiquitin protein ligase 1
  pellino E3 ubiquitin protein ligase family member 2
  peroxiredoxin 1
  phosphofructokinase, liver type
  phosphoinositide-3-kinase adaptor protein 1
  pleckstrin homology domain containing A4
  Rac family small GTPase 1
  ring finger protein 4
  RNA polymerase I and III subunit C
  SAM and SH3 domain containing 1
  sequestosome 1
  siah E3 ubiquitin protein ligase 1
  siah E3 ubiquitin protein ligase 2
  signal transducing adaptor family member 2
  SMAD specific E3 ubiquitin protein ligase 1
  speckle type BTB/POZ protein
  speckle type BTB/POZ protein like
  spleen associated tyrosine kinase
  sterile alpha and TIR motif containing 1
  thioredoxin
  TIR domain containing adaptor protein
  TNF receptor associated factor 3
  TNF receptor associated factor 6
  TNF receptor superfamily member 13B
  TNFAIP3 interacting protein 1
  toll like receptor 10
  toll like receptor 2
  toll like receptor 3
  toll like receptor 4
  toll like receptor 5
  toll like receptor 7
  toll like receptor 8
  toll like receptor 9
  tripartite motif containing 28
  tumor susceptibility 101
  ubiquitin associated protein 1
  ubiquitin specific peptidase 7
  zinc finger protein 35

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.