PEX14, peroxisomal biogenesis factor 14

PEX14, peroxisomal biogenesis factor 14

• This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]

• Gene Synonyms (peroxisomal membrane protein PEX14, NF-E2 associated polypeptide 2, PTS1 receptor docking protein, peroxin-14, peroxisomal membrane anchor protein PEX14, peroxisomal membrane anchor protein Pex14p, NAPP2, PBD13A, Pex14p, dJ734G22.2,)
• NCBI Gene ID: 5195
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75381
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

peroxisomal biogenesis factor 14 interacts with:

• alkylglycerone phosphate synthase
  ATP binding cassette subfamily D member 3
  ATPase family AAA domain containing 1
  ATR interacting protein
  C-C motif chemokine ligand 4
  CCR4-NOT transcription complex subunit 1
  centromere protein K
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  ciliary rootlet coiled-coil, rootletin
  COP9 signalosome subunit 4
  dehydrogenase/reductase 4
  dynamin 1 like
  dynein cytoplasmic 2 heavy chain 1
  fatty acyl-CoA reductase 1
  G protein-coupled receptor 156
  glyceronephosphate O-acyltransferase
  homer scaffold protein 3
  IKAROS family zinc finger 5
  IQ motif containing GTPase activating protein 1
  IQ motif containing GTPase activating protein 2
  leucine rich pentatricopeptide repeat containing
  mediator complex subunit 8
  meiosis regulator and mRNA stability factor 1
  MIER family member 2
  mitogen-activated protein kinase kinase 2
  nucleoporin 35
  patatin like phospholipase domain containing 2
  patatin like phospholipase domain containing 3
  peroxisomal biogenesis factor 14
  peroxisomal biogenesis factor 16
  peroxisomal biogenesis factor 19
  peroxisomal biogenesis factor 2
  peroxisomal biogenesis factor 26
  peroxisomal biogenesis factor 3
  peroxisomal biogenesis factor 5
  prolyl 4-hydroxylase subunit alpha 3
  protein kinase C substrate 80K-H
  Rho/Rac guanine nucleotide exchange factor 2
  ribosomal protein L28
  sirtuin 6
  solute carrier family 27 member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  t-complex 1
  tetratricopeptide repeat domain 1
  translocase of outer mitochondrial membrane 20
  translocase of outer mitochondrial membrane 22
  tubulin alpha 1a
  tubulin alpha 4a
  tubulin beta 2A class IIa
  tubulin beta 2B class IIb
  tubulin beta 3 class III
  tubulin beta 4A class IVa
  tubulin beta 4B class IVb
  tubulin beta 6 class V
  tubulin beta 8 class VIII
  tubulin beta class I
  tubulin gamma 2
  tumor protein p63
  VAMP associated protein A
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.