- Gene Overview
- Interaction Network
- Sequence Verification
PPBP, pro-platelet basic protein
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The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]
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Gene Synonyms (platelet basic protein, C-X-C motif chemokine 7, CXC chemokine ligand 7, beta-thromboglobulin, chemokine (C-X-C motif) ligand 7, connective tissue-activating peptide III, leukocyte-derived growth factor, low-affinity platelet factor IV, macrophage-derived growth factor, neutrophil-activating peptide 2, small inducible cytokine B7, small inducible cytokine subfamily B, member 7, thrombocidin 1, thrombocidin 2, thromboglobulin, beta-1, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1,)
- NCBI Gene ID:
5473
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>P02775
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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pro-platelet basic protein interacts with:
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this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
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