PTGS1, prostaglandin-endoperoxide synthase 1

PTGS1, prostaglandin-endoperoxide synthase 1

• This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

• Gene Synonyms (prostaglandin G/H synthase 1, PGH synthase 1, cyclooxygenase-1, prostaglandin H2 synthase 1, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS,)
• NCBI Gene ID: 5742
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P23219
  UNIPROT ID#>>A0A087X296
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prostaglandin-endoperoxide synthase 1 interacts with:

• F-box protein 6
  prostaglandin-endoperoxide synthase 1
  prostaglandin-endoperoxide synthase 2
  ring finger protein 123
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.