PTS, 6-pyruvoyltetrahydropterin synthase

PTS, 6-pyruvoyltetrahydropterin synthase

• The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008]

• Gene Synonyms (6-pyruvoyl tetrahydrobiopterin synthase, PTP synthase, truncated 6-pyruvoyltetrahydropterin synthase, PTPS,)
• NCBI Gene ID: 5805
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q03393
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

6-pyruvoyltetrahydropterin synthase interacts with:

• 6-pyruvoyltetrahydropterin synthase
  adenosylhomocysteinase like 1
  ankyrin repeat and SOCS box containing 1
  ankyrin repeat and SOCS box containing 5
  argonaute RISC component 4
  coilin
  DDB1 and CUL4 associated factor 15
  DNA damage inducible transcript 4 like
  fibronectin type III domain containing 5
  FMR1 autosomal homolog 2
  GTF2H2 family member C, copy 2
  ligand of numb-protein X 1
  N-terminal glutamine amidase 1
  polybromo 1
  SMAD specific E3 ubiquitin protein ligase 1
  suppressor of cytokine signaling 1
  synaptophysin
  syndecan binding protein
  TAFA chemokine like family member 4
  testis expressed 29
  THAP domain containing 10
  ubiquitin conjugating enzyme E2 M
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.