SELP, selectin P

SELP, selectin P

• This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]

• Gene Synonyms (P-selectin, CD62 antigen-like family member P, GMP-140, granule membrane protein 140, granule membrane protein 140kDa, granulocyte membrane protein, leukocyte-endothelial cell adhesion molecule 3, platelet activation dependent granule-external membrane protein, platelet alpha-granule membrane protein, selectin P (granule membrane protein 140kDa, antigen CD62), CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL,)
• NCBI Gene ID: 6403
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6NUL9
  UNIPROT ID#>>Q5R341
  UNIPROT ID#>>P16109
  UNIPROT ID#>>A0A024R8Y9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

selectin P interacts with:

• adaptor related protein complex 1 subunit mu 1
  CD24 molecule
  ezrin
  selectin P
  selectin P ligand
  sorting nexin 17
  sorting nexin 27

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.