STK10, serine/threonine kinase 10

STK10, serine/threonine kinase 10

• This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]

• Gene Synonyms (serine/threonine-protein kinase 10, lymphocyte-oriented kinase, LOK, PRO2729,)
• NCBI Gene ID: 6793
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O94804
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

serine/threonine kinase 10 interacts with:

• exportin 1
  nuclear RNA export factor 1
  pleckstrin homology domain containing A4
  serine/threonine kinase 10
  TNFAIP3 interacting protein 2
  TRAF family member associated NFKB activator
  tripartite motif containing 25
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.