SLBP, stem-loop binding protein

SLBP, stem-loop binding protein

• This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

• Gene Synonyms (histone RNA hairpin-binding protein, hairpin binding protein, histone, histone binding protein, histone stem-loop binding protein, stem-loop (histone) binding protein, HBP,)
• NCBI Gene ID: 7884
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DUW7
  UNIPROT ID#>>Q53XR2
  UNIPROT ID#>>B3KSC5
  UNIPROT ID#>>E7EUV9
  UNIPROT ID#>>Q14493
  UNIPROT ID#>>B3KST9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

stem-loop binding protein interacts with:

• cap binding complex dependent translation initiation factor
  cleavage and polyadenylation specific factor 3
  cullin 1
  cullin 2
  cullin 4A
  DDB1 and CUL4 associated factor 11
  exoribonuclease 1
  fem-1 homolog A
  fem-1 homolog B
  fem-1 homolog C
  H2B clustered histone 8
  La ribonucleoprotein 7, transcriptional regulator
  LSM10, U7 small nuclear RNA associated
  methylphosphate capping enzyme
  MIF4G domain containing
  prolyl 4-hydroxylase subunit alpha 3
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  splicing factor 3b subunit 1
  terminal uridylyl transferase 7
  transforming acidic coiled-coil containing protein 3
  ubiquitin specific peptidase 8
  zinc finger C3H1-type containing
  zinc finger protein 473

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.