DUSP11, dual specificity phosphatase 11

DUSP11, dual specificity phosphatase 11

• The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]

• Gene Synonyms (RNA/RNP complex-1-interacting phosphatase, RNA/RNP complex 1-interacting, RNA/RNP complex-interacting phosphatase, dual specificity protein phosphatase 11, phosphatase that interacts with RNA/RNP complex 1, serine/threonine specific protein phosphatase, PIR1,)
• NCBI Gene ID: 8446
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75319
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dual specificity phosphatase 11 interacts with:

• adenosylhomocysteinase like 2
  amyloid beta precursor protein binding family A member 3
  apolipoprotein B mRNA editing enzyme catalytic subunit 3D
  cold shock domain containing E1, RNA binding
  dual specificity phosphatase 11
  F-box and WD repeat domain containing 11
  kelch like family member 40
  mitochondrial ribosomal protein L13
  mitochondrial ribosomal protein L15
  mitochondrial ribosomal protein L18
  mitochondrial ribosomal protein L19
  mitochondrial ribosomal protein L21
  mitochondrial ribosomal protein L22
  mitochondrial ribosomal protein L24
  mitochondrial ribosomal protein L38
  mitochondrial ribosomal protein L4
  mitochondrial ribosomal protein L44
  mitochondrial ribosomal protein L50
  mitochondrial ribosomal protein S10
  mitochondrial ribosomal protein S11
  mitochondrial ribosomal protein S15
  mitochondrial ribosomal protein S16
  mitochondrial ribosomal protein S2
  mitochondrial ribosomal protein S21
  mitochondrial ribosomal protein S25
  mitochondrial ribosomal protein S26
  mitochondrial ribosomal protein S35
  mitochondrial ribosomal protein S7
  NIPA like domain containing 4
  pleckstrin homology domain containing A4
  potassium channel tetramerization domain containing 17
  proline rich 11
  prostaglandin E synthase 3
  serine and arginine rich splicing factor 9
  synaptotagmin binding cytoplasmic RNA interacting protein
  THO complex 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.