ACKR2, atypical chemokine receptor 2

ACKR2, atypical chemokine receptor 2

• This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

• Gene Synonyms (atypical chemokine receptor 2, C-C chemokine receptor D6, CC-chemokine-binding receptor JAB61, chemokine (C-C motif) receptor 9, chemokine (C-C) receptor 9, chemokine receptor CCR-10, chemokine receptor CCR-9, chemokine receptor D6, chemokine-binding protein 2, chemokine-binding protein D6, CCBP2, CCR10, CCR9, CMKBR9, D6, hD6,)
• NCBI Gene ID: 1238
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R2X7
  UNIPROT ID#>>O00590
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

atypical chemokine receptor 2 interacts with:

• cAMP responsive element binding protein 3
  C-C motif chemokine ligand 11
  C-C motif chemokine ligand 13
  C-C motif chemokine ligand 14
  C-C motif chemokine ligand 19
  C-C motif chemokine ligand 2
  C-C motif chemokine ligand 21
  C-C motif chemokine ligand 25
  C-C motif chemokine ligand 27
  C-C motif chemokine ligand 28
  C-C motif chemokine ligand 3
  C-C motif chemokine ligand 3 like 3
  C-C motif chemokine ligand 4
  C-C motif chemokine ligand 5
  C-C motif chemokine ligand 7
  C-C motif chemokine ligand 8
  chemokine (C-C motif) ligand 2
  chemokine (C-C motif) ligand 3
  cyclin dependent kinase 18
  ephrin A5
  gap junction protein alpha 8
  NIPA like domain containing 4
  SAC1 like phosphatidylinositide phosphatase
  solute carrier family 13 member 4
  transmembrane protein 167B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.