ETF1, eukaryotic translation termination factor 1

ETF1, eukaryotic translation termination factor 1

• This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

• Gene Synonyms (D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1, eukaryotic peptide chain release factor subunit 1, polypeptide chain release factor 1, protein Cl1, sup45 (yeast omnipotent suppressor 45) homolog-like 1,)
• NCBI Gene ID: 2107
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P62495
  UNIPROT ID#>>B7Z7P8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation termination factor 1 interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  ariadne RBR E3 ubiquitin protein ligase 1
  ATP binding cassette subfamily E member 1
  BAG cochaperone 6
  basic leucine zipper and W2 domains 1
  centrosomal protein 43
  coronin 1B
  coronin 1C
  DDB1 and CUL4 associated factor 15
  DNA ligase 4
  DnaJ heat shock protein family (Hsp40) member B1
  DnaJ heat shock protein family (Hsp40) member B4
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation initiation factor 2 subunit beta
  exportin 1
  fibrinogen beta chain
  fibronectin type III and SPRY domain containing 1
  G1 to S phase transition 1
  G1 to S phase transition 1
  G1 to S phase transition 2
  G3BP stress granule assembly factor 1
  gem nuclear organelle associated protein 5
  general transcription factor IIE subunit 2
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  histone deacetylase 4
  hypoxia up-regulated 1
  integrin alpha FG-GAP repeat containing 1
  karyopherin subunit beta 1
  kelch like ECH associated protein 1
  KRAS proto-oncogene, GTPase
  leucyl-tRNA synthetase 1
  methyl-CpG binding domain protein 5
  mitochondrial ribosomal protein S11
  M-phase phosphoprotein 9
  NCK associated protein 1
  nuclear distribution C, dynein complex regulator
  nuclear receptor subfamily 2 group C member 2
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  programmed cell death 4
  proteasome 20S subunit alpha 1
  protein phosphatase 2 catalytic subunit alpha
  ribosomal protein S7
  ring finger protein 26
  RTF1 homolog, Paf1/RNA polymerase II complex component
  small glutamine rich tetratricopeptide repeat containing beta
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  solute carrier family 38 member 7
  synapse associated protein 1
  translin
  tubulin, epsilon 1
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 47
  UPF1 RNA helicase and ATPase
  VPS26, retromer complex component A
  zinc finger DHHC-type palmitoyltransferase 18
  zinc finger DHHC-type palmitoyltransferase 23
  ZPR1 zinc finger

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.