EZH1, enhancer of zeste 1 polycomb repressive complex 2 subunit

EZH1, enhancer of zeste 1 polycomb repressive complex 2 subunit

• EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]

• Gene Synonyms (KMT6B, histone-lysine N-methyltransferase EZH1, ENX-2, enhancer of zeste homolog 1,)
• NCBI Gene ID: 2145
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92800
  UNIPROT ID#>>A0A0A0MSY9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

enhancer of zeste 1 polycomb repressive complex 2 subunit interacts with:

• AE binding protein 2
  elongin BC and polycomb repressive complex 2 associated protein
  embryonic ectoderm development
  enhancer of zeste 1 polycomb repressive complex 2 subunit
  enhancer of zeste 2 polycomb repressive complex 2 subunit
  GATA binding protein 4
  jumonji and AT-rich interaction domain containing 2
  ligand dependent nuclear receptor corepressor
  metal response element binding transcription factor 2
  PHD finger protein 1
  PHD finger protein 19
  protein arginine methyltransferase 5
  RB binding protein 4, chromatin remodeling factor
  RB binding protein 7, chromatin remodeling factor
  SKI/DACH domain containing 1
  SUZ12 polycomb repressive complex 2 subunit
  zinc finger MYND-type containing 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.