HSD17B4, hydroxysteroid 17-beta dehydrogenase 4

HSD17B4, hydroxysteroid 17-beta dehydrogenase 4

• The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

• Gene Synonyms (peroxisomal multifunctional enzyme type 2, 17-beta-HSD 4, 17-beta-HSD IV, 17-beta-hydroxysteroid dehydrogenase 4, 17beta-estradiol dehydrogenase type IV, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase, D-3-hydroxyacyl-CoA dehydratase, D-bifunctional protein, peroxisomal, beta-hydroxyacyl dehydrogenase, beta-keto-reductase, epididymis secretory sperm binding protein, hydroxysteroid dehydrogenase 4, multifunctional protein 2, peroxisomal multifunctional protein 2, short chain dehydrogenase/reductase family 8C member 1, DBP, MFE-2, MFP-2, MPF-2, PRLTS1, SDR8C1,)
• NCBI Gene ID: 3295
• Species: Homo sapiens (Human)
• UNIPROT ID#>>G5E9S2
  UNIPROT ID#>>P51659
  UNIPROT ID#>>B2R659
  UNIPROT ID#>>A0A0S2Z4J1
  UNIPROT ID#>>E7EWE5
  UNIPROT ID#>>B3KSP2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hydroxysteroid 17-beta dehydrogenase 4 interacts with:

• 3-hydroxyacyl-CoA dehydratase 3
  aldehyde dehydrogenase 16 family member A1
  arginyl-tRNA synthetase 1
  BICD cargo adaptor 2
  cell division cycle 73
  coiled-coil domain containing 8
  coronin 1C
  cullin 4B
  cullin 7
  cysteinyl-tRNA synthetase 2, mitochondrial
  cytochrome b5 reductase 1
  dual specificity phosphatase 22
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  ER membrane protein complex subunit 2
  fission, mitochondrial 1
  glyoxylate and hydroxypyruvate reductase
  heat shock protein family D (Hsp60) member 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  IKAROS family zinc finger 1
  interleukin enhancer binding factor 3
  isocitrate dehydrogenase (NADP(+)) 1
  kinase suppressor of ras 1
  leucine rich repeat containing 59
  leucyl-tRNA synthetase 1
  lysyl-tRNA synthetase 1
  metaxin 2
  mitogen-activated protein kinase 8
  MYC proto-oncogene, bHLH transcription factor
  neural precursor cell expressed, developmentally down-regulated gene 1
  neurofibromin 2
  neurotrophic receptor tyrosine kinase 1
  N-myc downstream regulated 1
  NRAS proto-oncogene, GTPase
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  peroxiredoxin 3
  peroxisomal biogenesis factor 14
  peroxisomal biogenesis factor 5
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  pleckstrin homology domain containing A4
  prohibitin 2
  prolyl-tRNA synthetase 2, mitochondrial
  protein phosphatase, Mg2+/Mn2+ dependent 1A
  pyruvate dehydrogenase complex component X
  pyruvate dehydrogenase E1 subunit alpha 1
  Rac GTPase activating protein 1
  receptor for activated C kinase 1
  RecQ like helicase 4
  RPGR interacting protein 1
  saccharopine dehydrogenase (putative)
  single stranded DNA binding protein 1
  solute carrier family 25 member 13
  sortilin 1
  spermatogenesis associated 7
  staufen double-stranded RNA binding protein 1
  sterol carrier protein 2
  succinate dehydrogenase complex flavoprotein subunit A
  synuclein alpha
  tubulin alpha 1a
  ubiquitin C
  ubiquitin like modifier activating enzyme 5
  vesicle associated membrane protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.