KARS1, lysyl-tRNA synthetase 1

KARS1, lysyl-tRNA synthetase 1

• Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CMTRIB, DFNB89, KARS, KARS2, KRS, lysine--tRNA ligase, lysRS, lysine tRNA ligase,)
• NCBI Gene ID: 3735
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15046
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lysyl-tRNA synthetase 1 interacts with:

• 3-hydroxyacyl-CoA dehydratase 3
  aldehyde dehydrogenase 16 family member A1
  aminoacyl tRNA synthetase complex interacting multifunctional protein 1
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  arginyl-tRNA synthetase 1
  asparaginyl-tRNA synthetase 1
  aspartyl-tRNA synthetase 2, mitochondrial
  ataxin 3
  ATP binding cassette subfamily E member 1
  aurora kinase A interacting protein 1
  Bet1 golgi vesicular membrane trafficking protein
  cell division cycle 73
  chaperonin containing TCP1 subunit 8
  chromosome 1 open reading frame 131
  COP9 signalosome subunit 5
  coronin 1B
  coronin 1C
  cullin 1
  cullin associated and neddylation dissociated 1
  cytochrome c oxidase assembly factor COX14
  cytokine induced apoptosis inhibitor 1
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation elongation factor 1 epsilon 1
  ezrin
  Fas associated factor 1
  F-box protein 6
  fibroblast growth factor receptor substrate 3
  gem nuclear organelle associated protein 4
  glutaminyl-tRNA synthetase 1
  H4 clustered histone 1
  HEXIM P-TEFb complex subunit 1
  importin 7
  integrin alpha FG-GAP repeat containing 1
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  keratin 17
  kinectin 1
  KRAS proto-oncogene, GTPase
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucine rich pentatricopeptide repeat containing
  leucine rich repeat containing 59
  leucyl-tRNA synthetase 1
  limb development membrane protein 1 like
  LRR binding FLII interacting protein 2
  lysine demethylase 6B
  mab-21 like 2
  MDM2 proto-oncogene
  mediator complex subunit 23
  mediator complex subunit 4
  methionyl-tRNA synthetase 1
  minichromosome maintenance complex component 2
  mitochondrial ribosomal protein S18B
  mitogen-activated protein kinase 1
  mutS homolog 3
  MYC proto-oncogene, bHLH transcription factor
  neurotrophic receptor tyrosine kinase 1
  nuclear distribution C, dynein complex regulator
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  nucleosome assembly protein 1 like 4
  OFD1 centriole and centriolar satellite protein
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  phosphoinositide-3-kinase regulatory subunit 3
  PIH1 domain containing 1
  plasminogen receptor with a C-terminal lysine
  platelet activating factor acetylhydrolase 1b regulatory subunit 1
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 8
  prohibitin
  proteasome 20S subunit alpha 3
  protein kinase N2
  protein phosphatase methylesterase 1
  protein phosphatase, Mg2+/Mn2+ dependent 1B
  PTEN induced kinase 1
  pyruvate dehydrogenase complex component X
  pyruvate dehydrogenase kinase 1
  RAB11A, member RAS oncogene family
  RAB27A, member RAS oncogene family
  RAB5A, member RAS oncogene family
  RAB9A, member RAS oncogene family
  RAD18 E3 ubiquitin protein ligase
  RAN binding protein 6
  RecQ like helicase 4
  ribosomal protein L17
  ribosomal protein L19
  ribosomal protein L21
  ribosomal protein L36
  ribosomal protein SA
  ring finger protein 123
  ring finger protein 181
  serologically defined colon cancer antigen 8
  SH3 domain containing ring finger 2
  SHH signaling and ciliogenesis regulator SDCCAG8
  sideroflexin 1
  signal transducer and activator of transcription 1
  sirtuin 7
  small RNA binding exonuclease protection factor La
  sorting nexin 8
  spectrin alpha, non-erythrocytic 1
  staufen double-stranded RNA binding protein 1
  sterile alpha motif domain containing 9
  superoxide dismutase 1
  taxilin alpha
  threonyl-tRNA synthetase 3
  TNFAIP3 interacting protein 2
  trans-golgi network protein 2
  translocase of outer mitochondrial membrane 22
  tripartite motif containing 28
  tRNA methyltransferase 1
  ubiquitin conjugating enzyme E2 S
  ubiquitin like modifier activating enzyme 1
  VHL binding protein 1
  vimentin
  vir like m6A methyltransferase associated
  WD repeat domain 61
  WW domain containing E3 ubiquitin protein ligase 2
  X-prolyl aminopeptidase 1
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.