HSPD1, heat shock protein family D (Hsp60) member 1

HSPD1, heat shock protein family D (Hsp60) member 1

• This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]

• Gene Synonyms (60 kDa heat shock protein, mitochondrial, 60 kDa chaperonin, P60 lymphocyte protein, chaperonin 60, epididymis secretory sperm binding protein, heat shock 60kDa protein 1 (chaperonin), heat shock protein 65, mitochondrial matrix protein P1, short heat shock protein 60 Hsp60s1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13,)
• NCBI Gene ID: 3329
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P10809
  UNIPROT ID#>>A0A024R3X4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heat shock protein family D (Hsp60) member 1 interacts with:

• 3-hydroxyisobutyryl-CoA hydrolase
  3-oxoacid CoA-transferase 1
  3-oxoacid CoA-transferase 2
  5'-nucleotidase domain containing 2
  5'-nucleotidase domain containing 3
  AAR2 splicing factor
  abhydrolase domain containing 10, depalmitoylase
  abhydrolase domain containing 18
  acetyl-CoA acyltransferase 2
  activator of HSP90 ATPase activity 1
  acyl-CoA dehydrogenase family member 9
  acyl-CoA synthetase family member 2
  acyl-CoA synthetase family member 3
  acyl-CoA synthetase short chain family member 1
  acyl-CoA thioesterase 1
  acyl-CoA thioesterase 2
  acyl-CoA thioesterase 9
  adenylate kinase 3
  AFG3 like matrix AAA peptidase subunit 2
  AKT interacting protein
  alanyl-tRNA synthetase 2, mitochondrial
  aldehyde dehydrogenase 18 family member A1
  aminoadipate-semialdehyde synthase
  ankyrin repeat and SOCS box containing 4
  ankyrin repeat and SOCS box containing 9
  anterior gradient 2, protein disulphide isomerase family member
  arachidonate lipoxygenase 3
  asparaginyl-tRNA synthetase 2, mitochondrial
  aspartyl-tRNA synthetase 2, mitochondrial
  ataxin 3
  ATP synthase mitochondrial F1 complex assembly factor 1
  ATP synthase mitochondrial F1 complex assembly factor 2
  ATP synthase peripheral stalk subunit d
  ATPase family AAA domain containing 3B
  aurora kinase A
  aurora kinase A interacting protein 1
  aurora kinase B
  autophagy and beclin 1 regulator 1
  autophagy related 16 like 1
  BCL6 corepressor
  BICD cargo adaptor 2
  bromodomain containing 7
  caseinolytic mitochondrial matrix peptidase chaperone subunit X
  caseinolytic mitochondrial matrix peptidase proteolytic subunit
  CCCTC-binding factor
  CDKN2A interacting protein
  CDKN2A interacting protein
  cell cycle and apoptosis regulator 2
  cell division cycle 73
  centrosomal protein 70
  chromosome 11 open reading frame 58
  chromosome 17 open reading frame 80
  chromosome 8 open reading frame 82
  chromosome X open reading frame 56
  coiled-coil domain containing 8
  collagen beta(1-O)galactosyltransferase 1
  COP9 signalosome subunit 5
  C-type lectin domain containing 7A
  cullin 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin 7
  cullin associated and neddylation dissociated 1
  cysteine rich tail 1
  cysteinyl-tRNA synthetase 2, mitochondrial
  cytoskeleton associated protein 5
  DDB1 and CUL4 associated factor 4
  DDB1 and CUL4 associated factor 4 like 2
  DDB1 and CUL4 associated factor 5
  DEAD-box helicase 17
  death associated protein 3
  dehydrogenase E1 and transketolase domain containing 1
  DExD-box helicase 39B
  dickkopf WNT signaling pathway inhibitor 3
  DNA cross-link repair 1B
  DNA polymerase delta interacting protein 2
  DNA polymerase gamma, catalytic subunit
  DnaJ heat shock protein family (Hsp40) member A3
  dual specificity phosphatase 12
  dual specificity phosphatase 13
  dual specificity phosphatase 19
  EEF1A lysine methyltransferase 3
  egl-9 family hypoxia inducible factor 3
  elaC ribonuclease Z 2
  electron transfer flavoprotein subunit beta lysine methyltransferase
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  enoyl-CoA delta isomerase 2
  ER degradation enhancing alpha-mannosidase like protein 3
  Era like 12S mitochondrial rRNA chaperone 1
  FAD dependent oxidoreductase domain containing 1
  family with sequence similarity 107 member A
  Fas associated factor 1
  F-box and leucine rich repeat protein 6
  F-box protein 15
  F-box protein 17
  F-box protein 6
  F-box protein 7
  flavin adenine dinucleotide synthetase 1
  fumarylacetoacetate hydrolase domain containing 2B
  G elongation factor mitochondrial 1
  G3BP stress granule assembly factor 1
  galactosidase beta 1 like 3
  galectin 3 binding protein
  GDP-mannose pyrophosphorylase B
  GID complex subunit 8 homolog
  gigaxonin
  glutaminyl-tRNA amidotransferase subunit QRSL1
  glutamyl-tRNA amidotransferase subunit B
  glutamyl-tRNA amidotransferase subunit C
  glutaredoxin 5
  glutathione S-transferase kappa 1
  glyoxalase domain containing 4
  golgi reassembly stacking protein 1
  GTP binding protein 8 (putative)
  guanine deaminase
  guanine nucleotide binding protein (G protein), beta 1
  H2B clustered histone 21
  H3 clustered histone 6
  H4 clustered histone 1
  haloacid dehalogenase like hydrolase domain containing 5
  HCLS1 associated X-1
  heat shock protein family D (Hsp60) member 1
  heat shock protein family E (Hsp10) member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  high mobility group 20A
  histidine triad nucleotide binding protein 2
  histidyl-tRNA synthetase 2, mitochondrial
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 6
  hydroxysteroid dehydrogenase like 2
  inorganic pyrophosphatase 1
  inorganic pyrophosphatase 2
  integrin alpha FG-GAP repeat containing 1
  integrin subunit alpha 1
  integrin subunit alpha 3
  integrin subunit alpha 4
  integrin subunit beta 1
  interferon alpha and beta receptor subunit 1
  iron-sulfur cluster assembly factor IBA57
  ISG15 ubiquitin like modifier
  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
  isoleucyl-tRNA synthetase 2, mitochondrial
  kelch like family member 33
  keratin 17
  keratin 31
  keratin 34
  keratin 40
  keratin associated protein 10-3
  keratin associated protein 10-8
  keratin associated protein 5-9
  KRAS proto-oncogene, GTPase
  La ribonucleoprotein 7, transcriptional regulator
  laminin subunit beta 1
  laminin subunit beta 3
  leucine rich pentatricopeptide repeat containing
  leucine rich repeat containing 28
  leucine rich repeat containing G protein-coupled receptor 4
  leucine rich repeat kinase 2
  leucine zipper and EF-hand containing transmembrane protein 1
  leucine zipper tumor suppressor 2
  leucyl-tRNA synthetase 1
  leucyl-tRNA synthetase 2, mitochondrial
  lon peptidase 1, mitochondrial
  LYR motif containing 4
  LYR motif containing 7
  lysophospholipase like 1
  MAGE family member A3
  malate dehydrogenase 2
  malic enzyme 2
  metabolism of cobalamin associated B
  methionyl-tRNA synthetase 2, mitochondrial
  methylcrotonoyl-CoA carboxylase 2
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 17
  methyltransferase like 3
  methyltransferase like 8
  microcephalin 1
  minichromosome maintenance complex component 2
  mitochondrial carrier 2
  mitochondrial genome maintenance exonuclease 1
  mitochondrial ribosomal protein L1
  mitochondrial ribosomal protein L10
  mitochondrial ribosomal protein L12
  mitochondrial ribosomal protein L13
  mitochondrial ribosomal protein L14
  mitochondrial ribosomal protein L16
  mitochondrial ribosomal protein L19
  mitochondrial ribosomal protein L20
  mitochondrial ribosomal protein L21
  mitochondrial ribosomal protein L24
  mitochondrial ribosomal protein L27
  mitochondrial ribosomal protein L3
  mitochondrial ribosomal protein L37
  mitochondrial ribosomal protein L38
  mitochondrial ribosomal protein L39
  mitochondrial ribosomal protein L4
  mitochondrial ribosomal protein L41
  mitochondrial ribosomal protein L42
  mitochondrial ribosomal protein L43
  mitochondrial ribosomal protein L44
  mitochondrial ribosomal protein L45
  mitochondrial ribosomal protein L46
  mitochondrial ribosomal protein L47
  mitochondrial ribosomal protein L48
  mitochondrial ribosomal protein L50
  mitochondrial ribosomal protein L53
  mitochondrial ribosomal protein L58
  mitochondrial ribosomal protein L9
  mitochondrial ribosomal protein S10
  mitochondrial ribosomal protein S11
  mitochondrial ribosomal protein S14
  mitochondrial ribosomal protein S15
  mitochondrial ribosomal protein S16
  mitochondrial ribosomal protein S17
  mitochondrial ribosomal protein S18B
  mitochondrial ribosomal protein S18C
  mitochondrial ribosomal protein S2
  mitochondrial ribosomal protein S21
  mitochondrial ribosomal protein S22
  mitochondrial ribosomal protein S23
  mitochondrial ribosomal protein S24
  mitochondrial ribosomal protein S25
  mitochondrial ribosomal protein S26
  mitochondrial ribosomal protein S27
  mitochondrial ribosomal protein S28
  mitochondrial ribosomal protein S30
  mitochondrial ribosomal protein S31
  mitochondrial ribosomal protein S33
  mitochondrial ribosomal protein S34
  mitochondrial ribosomal protein S35
  mitochondrial ribosomal protein S36
  mitochondrial ribosomal protein S5
  mitochondrial ribosomal protein S6
  mitochondrial ribosomal protein S7
  mitochondrial ribosomal protein S9
  mitochondrial ribosome associated GTPase 1
  mitochondrial ribosome associated GTPase 2
  mitochondrial rRNA methyltransferase 2
  mitochondrial rRNA methyltransferase 3
  mitochondrial transcription termination factor 3
  mitochondrial translational initiation factor 2
  mitogen-activated protein kinase 6
  mitogen-activated protein kinase kinase 3
  Mov10 RISC complex RNA helicase
  MYC proto-oncogene, bHLH transcription factor
  MYG1 exonuclease
  myotubularin 1
  myotubularin related protein 6
  myotubularin related protein 7
  myotubularin related protein 8
  N-acetylglucosamine kinase
  NADH:ubiquinone oxidoreductase complex assembly factor 1
  NADH:ubiquinone oxidoreductase complex assembly factor 2
  NADH:ubiquinone oxidoreductase complex assembly factor 3
  NADH:ubiquinone oxidoreductase complex assembly factor 4
  NADH:ubiquinone oxidoreductase complex assembly factor 5
  NADH:ubiquinone oxidoreductase complex assembly factor 7
  NADH:ubiquinone oxidoreductase core subunit S1
  NADH:ubiquinone oxidoreductase core subunit S2
  NADH:ubiquinone oxidoreductase core subunit S3
  NADH:ubiquinone oxidoreductase core subunit S7
  NADH:ubiquinone oxidoreductase core subunit S8
  NADH:ubiquinone oxidoreductase core subunit V1
  NADH:ubiquinone oxidoreductase core subunit V2
  NADH:ubiquinone oxidoreductase subunit A10
  NADH:ubiquinone oxidoreductase subunit A12
  NADH:ubiquinone oxidoreductase subunit A13
  NADH:ubiquinone oxidoreductase subunit A2
  NADH:ubiquinone oxidoreductase subunit A5
  NADH:ubiquinone oxidoreductase subunit A6
  NADH:ubiquinone oxidoreductase subunit A7
  NADH:ubiquinone oxidoreductase subunit A8
  NADH:ubiquinone oxidoreductase subunit A9
  NADH:ubiquinone oxidoreductase subunit S4
  NADH:ubiquinone oxidoreductase subunit S5
  NADH:ubiquinone oxidoreductase subunit S6
  nardilysin convertase
  NEDD8 ubiquitin like modifier
  neuraminidase 4
  neurotrophic receptor tyrosine kinase 1
  NFS1 cysteine desulfurase
  nicotinamide nucleotide transhydrogenase
  nipsnap homolog 1
  nipsnap homolog 3A
  nitric oxide synthase 1 adaptor protein
  nitric oxide synthase 2
  NME/NM23 nucleoside diphosphate kinase 4
  non-SMC condensin I complex subunit D2
  NOP2/Sun RNA methyltransferase 4
  notch 2 N-terminal like A
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  nuclear transcription factor, X-box binding 1
  nudix hydrolase 19
  nudix hydrolase 8
  obscurin like cytoskeletal adaptor 1
  optineurin
  ornithine aminotransferase
  oxidoreductase NAD binding domain containing 1
  oxoglutarate dehydrogenase
  palmitoyl-protein thioesterase 1
  par-3 family cell polarity regulator
  parathymosin
  parkin RBR E3 ubiquitin protein ligase
  pentatricopeptide repeat domain 1
  pentatricopeptide repeat domain 3
  peptidase, mitochondrial processing subunit alpha
  peptidase, mitochondrial processing subunit beta
  peptidylprolyl isomerase E
  peptidylprolyl isomerase F
  peroxiredoxin 3
  phosphatase and tensin homolog
  phosphodiesterase 12
  phosphoenolpyruvate carboxykinase 1
  phosphoenolpyruvate carboxykinase 2, mitochondrial
  phosphoethanolamine/phosphocholine phosphatase 1
  phospholipase C gamma 2
  PIH1 domain containing 1
  plasminogen
  pleckstrin homology domain containing A4
  poly(A) specific ribonuclease subunit PAN2
  poly(U) binding splicing factor 60
  polycomb group ring finger 1
  polyribonucleotide nucleotidyltransferase 1
  PRAME family member 17
  pre-mRNA processing factor 8
  prion protein
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
  prohibitin
  prolyl 4-hydroxylase subunit beta
  prolyl endopeptidase
  prolyl endopeptidase like
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, non-ATPase 14
  protein kinase C and casein kinase substrate in neurons 2
  protein kinase C and casein kinase substrate in neurons 3
  protein kinase cAMP-activated catalytic subunit alpha
  protein phosphatase 2 regulatory subunit Bgamma
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 2 scaffold subunit Abeta
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 14
  protein tyrosine phosphatase non-receptor type 18
  protein tyrosine phosphatase non-receptor type 2
  pseudouridine synthase 1
  pseudouridine synthase like 1
  PTEN induced kinase 1
  pyrroline-5-carboxylate reductase 1
  pyrroline-5-carboxylate reductase 2
  pyruvate dehydrogenase kinase 3
  pyruvate dehydrogenase phosphatase regulatory subunit
  queuine tRNA-ribosyltransferase catalytic subunit 1
  RAB10, member RAS oncogene family
  RAB1B, member RAS oncogene family
  RAB5B, member RAS oncogene family
  RAD18 E3 ubiquitin protein ligase
  RAD52 homolog, DNA repair protein
  Raf-1 proto-oncogene, serine/threonine kinase
  RAS like family 10 member B
  RAS p21 protein activator 1
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  regulator of G protein signaling 20
  regulator of solute carriers 1
  reticulon 4 interacting protein 1
  ribosomal protein S6 kinase B2
  ring finger and CCCH-type domains 1
  ring finger and WD repeat domain 3
  ring finger protein 123
  ring finger protein 31
  ring finger protein 4
  ring-box 1
  RIO kinase 1
  RNA exonuclease 2
  RNA polymerase II associated protein 1
  RNA pseudouridine synthase D3
  SAP domain containing ribonucleoprotein
  SAP30 binding protein
  septin 9
  serine hydroxymethyltransferase 2
  serine/arginine repetitive matrix 2
  serine/threonine/tyrosine interacting like 1
  seryl-tRNA synthetase 2, mitochondrial
  short chain dehydrogenase/reductase family 39U member 1
  sideroflexin 1
  single stranded DNA binding protein 1
  sirtuin 1
  sirtuin 3
  sirtuin 4
  SKI proto-oncogene
  SMAD specific E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 4
  snail family transcriptional repressor 1
  SNW domain containing 1
  solute carrier family 25 member 1
  solute carrier family 25 member 28
  solute carrier family 25 member 33
  solute carrier family 25 member 39
  solute carrier family 25 member 41
  solute carrier family 25 member 43
  spartin
  spermine synthase
  spindle and kinetochore associated complex subunit 1
  splicing factor 3a subunit 2
  SPRY domain containing 4
  SPT6 homolog, histone chaperone and transcription elongation factor
  SRA stem-loop interacting RNA binding protein
  SRY-box transcription factor 2
  staufen double-stranded RNA binding protein 1
  sterile alpha motif domain containing 3
  STIP1 homology and U-box containing protein 1
  striatin 4
  succinate dehydrogenase complex flavoprotein subunit A
  succinate dehydrogenase complex iron sulfur subunit B
  succinate-CoA ligase ADP-forming subunit beta
  succinate-CoA ligase GDP/ADP-forming subunit alpha
  Suv3 like RNA helicase
  tafazzin
  tensin 2
  tensin 3
  testis expressed 101
  tet methylcytosine dioxygenase 2
  tetratricopeptide repeat domain 39B
  thimet oligopeptidase 1
  thioesterase superfamily member 4
  threonine synthase like 1
  threonyl-tRNA synthetase 2, mitochondrial
  thrombospondin 3
  thymopoietin
  toll like receptor 1
  transcription factor A, mitochondrial
  transcription factor B1, mitochondrial
  transcription factor CP2
  transforming growth factor beta 1
  translational activator of cytochrome c oxidase I
  translocase of inner mitochondrial membrane 44
  transmembrane and coiled-coil domain family 2
  transmembrane protein 70
  transport and golgi organization 2 homolog
  tribbles pseudokinase 2
  trimethyllysine hydroxylase, epsilon
  tripartite motif containing 25
  tripartite motif containing 43
  tripartite motif containing 63
  tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
  tRNA methyltransferase 1
  tRNA methyltransferase 1 like
  tRNA methyltransferase 10C, mitochondrial RNase P subunit
  tRNA methyltransferase 11 homolog
  tRNA methyltransferase 2 homolog B
  tRNA methyltransferase 5
  tRNA methyltransferase 61B
  tRNA-histidine guanylyltransferase 1 like
  TruB pseudouridine synthase family member 2
  Ts translation elongation factor, mitochondrial
  tubulin alpha 1c
  tubulin beta 4B class IVb
  tubulin gamma 1
  tubulin gamma complex associated protein 3
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosyl-tRNA synthetase 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  ubiquinol-cytochrome c reductase complex assembly factor 1
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin like 4A
  ubiquitin protein ligase E3 component n-recognin 4
  unk zinc finger
  valosin containing protein
  valyl-tRNA synthetase 2, mitochondrial
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  von Willebrand factor A domain containing 8
  VRK serine/threonine kinase 1
  VRK serine/threonine kinase 3
  WD repeat domain 5
  X-ray repair cross complementing 3
  ybeY metalloendoribonuclease
  Yes1 associated transcriptional regulator
  YY1 associated factor 2
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.