HSF4, heat shock transcription factor 4

HSF4, heat shock transcription factor 4

• Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (heat shock factor protein 4, HSF 4, HSTF 4, hHSF4, CTM, CTRCT5,)
• NCBI Gene ID: 3299
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R6X7
  UNIPROT ID#>>Q9ULV5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heat shock transcription factor 4 interacts with:

• A-kinase anchoring protein 8 like
  alkB homolog 4, lysine demethylase
  chromosome 19 open reading frame 54
  cyclin dependent kinase 2 associated protein 2
  dual specificity phosphatase 26
  family with sequence similarity 168 member B
  forkhead box H1
  glucose-fructose oxidoreductase domain containing 1
  heat shock transcription factor 4
  hepatocyte growth factor-regulated tyrosine kinase substrate
  integrator complex subunit 11
  keratin 31
  keratin 37
  keratin 38
  keratin 40
  keratin associated protein 19-6
  keratin associated protein 19-7
  keratin associated protein 3-1
  keratin associated protein 6-2
  makorin ring finger protein 3
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase 8
  myosin XVA
  NHL repeat containing 4
  nucleoporin 62
  nudix hydrolase 21
  Opa interacting protein 5
  paired like homeodomain 1
  phospholipase A2 group X
  PIH1 domain containing 2
  PPFIA binding protein 2
  rabaptin, RAB GTPase binding effector protein 1
  SEC14 and spectrin domain containing 1
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  solute carrier family 27 member 5
  SRY-box transcription factor 10
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  TAR (HIV-1) RNA binding protein 1
  translocase of inner mitochondrial membrane 13
  tropomyosin 3
  tumor protein p63
  UFM1 specific peptidase 1 (inactive)
  YTH N6-methyladenosine RNA binding protein 1
  zinc finger BED-type containing 8
  zinc finger MYND-type containing 12

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.