IDH3A, isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

IDH3A, isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

• Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]

• Gene Synonyms (isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, H-IDH alpha, NAD(+)-specific ICDH subunit alpha, NAD(H)-specific isocitrate dehydrogenase alpha subunit, NAD+-specific ICDH, isocitrate dehydrogenase (NAD(+)) 3 alpha, isocitrate dehydrogenase (NAD+) alpha chain, isocitrate dehydrogenase 3 (NAD(+)) alpha, isocitrate dehydrogenase 3 (NAD+) alpha, isocitric dehydrogenase subunit alpha,)
• NCBI Gene ID: 3419
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z9J8
  UNIPROT ID#>>P50213
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha interacts with:

• ATP binding cassette subfamily C member 1
  ATP binding cassette subfamily C member 3
  chaperonin containing TCP1 subunit 6B
  chaperonin containing TCP1 subunit 8
  clathrin heavy chain like 1
  cullin 7
  DET1 and DDB1 associated 1
  developmental pluripotency-associated 3
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  importin 9
  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
  malate dehydrogenase 2
  malic enzyme 2
  mitochondrial rRNA methyltransferase 1
  muscleblind like splicing regulator 1
  MYC proto-oncogene, bHLH transcription factor
  nuclear factor of activated T cells 2
  nuclear receptor subfamily 2 group C member 2
  pleckstrin homology domain containing A4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 4
  protein phosphatase 2 scaffold subunit Aalpha
  pseudouridine 5'-phosphatase
  pyrroline-5-carboxylate reductase 1
  pyruvate dehydrogenase kinase 1
  RAB4A, member RAS oncogene family
  retinol dehydrogenase 13
  ribophorin I
  ribosomal protein lateral stalk subunit P0
  S100 calcium binding protein A16
  small ubiquitin like modifier 4
  solute carrier family 25 member 3
  staufen double-stranded RNA binding protein 1
  succinate dehydrogenase complex flavoprotein subunit A
  succinate-CoA ligase ADP-forming subunit beta
  succinate-CoA ligase GDP-forming subunit beta
  superoxide dismutase 1
  telomeric repeat binding factor 1
  telomeric repeat binding factor 2
  ubiquilin 2
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin conjugating enzyme E2 N

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.