NFATC2, nuclear factor of activated T cells 2

NFATC2, nuclear factor of activated T cells 2

• This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

• Gene Synonyms (NFAT1, NFATP, nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, NFAT pre-existing subunit, NFAT transcription complex, preexisting component, T cell transcription factor NFAT1, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2, nuclear factor of activated T-cells, preexisting component, preexisting nuclear factor of activated T-cells 2,)
• NCBI Gene ID: 4773
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B5B2P4
  UNIPROT ID#>>Q13469
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear factor of activated T cells 2 interacts with:

• activating transcription factor 7
  activity dependent neuroprotector homeobox
  aldehyde dehydrogenase 18 family member A1
  apoptosis inducing factor mitochondria associated 1
  AT-rich interaction domain 1A
  BAF chromatin remodeling complex subunit BCL11B
  BEN domain containing 3
  B-TFIID TATA-box binding protein associated factor 1
  calcineurin binding protein 1
  calcyclin binding protein
  chromatin assembly factor 1 subunit B
  chromobox 1
  chromobox 3
  chromobox 5
  chromosome alignment maintaining phosphoprotein 1
  DDB1 and CUL4 associated factor 7
  DEK proto-oncogene
  DNA polymerase delta interacting protein 2
  DNA polymerase gamma, catalytic subunit
  double PHD fingers 2
  Era like 12S mitochondrial rRNA chaperone 1
  forkhead box K1
  forkhead box P3
  GATA zinc finger domain containing 2A
  GATA zinc finger domain containing 2B
  general transcription factor IIIC subunit 4
  general transcription factor IIIC subunit 5
  GTF2H2 family member C
  GTF2H2 family member C, copy 2
  heat shock protein family H (Hsp110) member 1
  helicase like transcription factor
  histone cell cycle regulator
  IKAROS family zinc finger 1
  IKAROS family zinc finger 2
  interferon regulatory factor 2 binding protein 1
  interferon regulatory factor 2 binding protein 2
  IQ motif containing GTPase activating protein 1
  kinesin family member 2C
  kinesin family member 4A
  leucine rich repeat containing 47
  leucine rich repeat kinase 2
  lymphoid enhancer binding factor 1
  lysine demethylase 1A
  macroH2A.1 histone
  MAF bZIP transcription factor K
  mediator complex subunit 31
  metastasis associated 1
  metastasis associated 1 family member 2
  methyl-CpG binding domain protein 3
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
  microspherule protein 1
  mitochondrial ribosomal protein L17
  mitochondrial ribosomal protein L39
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 9
  NK2 homeobox 1
  nuclear distribution C, dynein complex regulator
  nuclear factor of activated T cells 2
  nuclear factor of activated T cells 2 interacting protein
  nuclear transcription factor Y subunit beta
  nuclear transcription factor Y subunit gamma
  peptidase, mitochondrial processing subunit beta
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  pogo transposable element derived with ZNF domain
  polo like kinase 1
  PR/SET domain 15
  protein kinase C zeta
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 3 catalytic subunit beta
  protein phosphatase 3 regulatory subunit B, alpha
  RAD50 double strand break repair protein
  RAN binding protein 2
  RAN binding protein 9
  RB binding protein 4, chromatin remodeling factor
  RB transcriptional corepressor 1
  regulatory associated protein of MTOR complex 1
  replication factor C subunit 2
  replication factor C subunit 3
  replication factor C subunit 4
  replication factor C subunit 5
  replication protein A1
  replication protein A2
  replication protein A3
  REST corepressor 1
  ribosomal protein L23
  RNA guanylyltransferase and 5'-phosphatase
  RNA polymerase I and III subunit C
  SATB homeobox 1
  single stranded DNA binding protein 1
  SPT5 homolog, DSIF elongation factor subunit
  SPT6 homolog, histone chaperone and transcription elongation factor
  structure specific recognition protein 1
  succinate dehydrogenase complex flavoprotein subunit A
  succinate-CoA ligase ADP-forming subunit beta
  suppressor of cancer cell invasion
  suppressor of variegation 3-9 homolog 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
  TATA-box binding protein associated factor 9
  t-complex 1
  tousled like kinase 1
  tousled like kinase 2
  transcription factor 12
  transcription factor A, mitochondrial
  transcription factor AP-4
  transformation/transcription domain associated protein
  translocase of inner mitochondrial membrane 50
  Tu translation elongation factor, mitochondrial
  tubulin alpha 1a
  tumor protein p53 binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin conjugating enzyme E2 S
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin specific peptidase 22
  VAMP associated protein A
  VAMP associated protein B and C
  vimentin
  vir like m6A methyltransferase associated
  WD repeat domain 26
  WD repeat domain 48
  X-ray repair cross complementing 1
  X-ray repair cross complementing 5
  zinc finger MYM-type containing 2
  zinc finger protein 131
  zinc finger protein 148
  zinc finger protein 217
  zinc finger protein 24
  zinc finger protein 384

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.