ITPA, inosine triphosphatase

ITPA, inosine triphosphatase

• This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

• Gene Synonyms (C20orf37, HLC14-06-P, ITPase, My049, NTPase, dJ794I6.3, inosine triphosphate pyrophosphatase, epididymis secretory sperm binding protein, inosine triphosphatase (nucleoside triphosphate pyrophosphatase), inosine triphosphate pyrophosphohydrolase, non-canonical purine NTP pyrophosphatase, non-standard purine NTP pyrophosphatase, nucleoside-triphosphate diphosphatase, putative oncogene protein HLC14-06-P,)
• NCBI Gene ID: 3704
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z423
  UNIPROT ID#>>Q8WWI0
  UNIPROT ID#>>A0A0S2Z3W7
  UNIPROT ID#>>Q9BY32
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

inosine triphosphatase interacts with:

• ADAM metallopeptidase with thrombospondin type 1 motif 4
  C-C motif chemokine ligand 22
  chromosome 9 open reading frame 64
  FAM3 metabolism regulating signaling molecule B
  fermitin family member 1
  gamma-glutamylcyclotransferase
  GrpE like 1, mitochondrial
  heterogeneous nuclear ribonucleoprotein A3
  inorganic pyrophosphatase 1
  inosine triphosphatase
  Mov10 RISC complex RNA helicase
  NSFL1 cofactor
  nuclear RNA export factor 1
  Parkinsonism associated deglycase
  PEDS1-UBE2V1 readthrough
  peptidylprolyl isomerase H
  peroxisome proliferator activated receptor gamma
  pleckstrin homology domain containing A4
  programmed cell death 6
  proteasome assembly chaperone 4
  purinergic receptor P2X 5
  pyridoxal kinase
  serine hydroxymethyltransferase 1
  serine hydroxymethyltransferase 2
  serpin family B member 11
  serpin family B member 2
  serpin family B member 5
  serpin family B member 6
  serpin family B member 8
  SS nuclear autoantigen 1
  stress induced phosphoprotein 1
  testin LIM domain protein
  thyroid stimulating hormone receptor
  torsin 1A interacting protein 2
  transketolase
  ubiquitin conjugating enzyme E2 V1
  ubiquitin specific peptidase 14
  uridine monophosphate synthetase
  vacuolar protein sorting 4 homolog B
  WD repeat domain 1
  Wnt family member 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.