MDM2, MDM2 proto-oncogene

MDM2, MDM2 proto-oncogene

• This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

• Gene Synonyms (ACTFS, HDMX, LSKB, hdm2, E3 ubiquitin-protein ligase Mdm2, MDM2 oncogene, E3 ubiquitin protein ligase, MDM2 proto-oncogene, E3 ubiquitin protein ligase, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, double minute 2, human homolog of; p53-binding protein, oncoprotein Mdm2,)
• NCBI Gene ID: 4193
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96DS0
  UNIPROT ID#>>A7UKX9
  UNIPROT ID#>>Q00987
  UNIPROT ID#>>A0A0A8KB75
  UNIPROT ID#>>A7UKX7
  UNIPROT ID#>>A7UKX8
  UNIPROT ID#>>G3XA89
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MDM2 proto-oncogene interacts with:

• aldehyde dehydrogenase 16 family member A1
  alkylglycerone phosphate synthase
  anaphase promoting complex subunit 2
  ankyrin repeat domain 17
  apoptosis antagonizing transcription factor
  arginyl-tRNA synthetase 1
  ariadne RBR E3 ubiquitin protein ligase 2
  aryl hydrocarbon receptor nuclear translocator like 2
  aurora kinase A
  BAG cochaperone 6
  BAR/IMD domain containing adaptor protein 2 like 1
  BCAR1 scaffold protein, Cas family member
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BTG3 associated nuclear protein
  calsyntenin 1
  caseinolytic mitochondrial matrix peptidase chaperone subunit B
  CDK5 regulatory subunit associated protein 3
  CDKN2A interacting protein
  cell cycle and apoptosis regulator 2
  cell division cycle and apoptosis regulator 1
  centromere protein X
  checkpoint kinase 2
  cms1 ribosomal small subunit homolog
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 5
  CREB regulated transcription coactivator 2
  CREB regulated transcription coactivator 3
  cullin 1
  cullin 4A
  cullin 4B
  CWC25 spliceosome associated protein homolog
  cyclin dependent kinase inhibitor 2A
  DDB1 and CUL4 associated factor 8
  DEAD-box helicase 17
  DEAD-box helicase 24
  DEAD-box helicase 42
  dehydrogenase/reductase 2
  denticleless E3 ubiquitin protein ligase homolog
  dermcidin
  DET1 partner of COP1 E3 ubiquitin ligase
  DIRAS family GTPase 3
  DNA polymerase epsilon, catalytic subunit
  DNA polymerase eta
  DNA topoisomerase I
  DnaJ heat shock protein family (Hsp40) member B4
  dual specificity tyrosine phosphorylation regulated kinase 2
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  enhancer of mRNA decapping 4
  EP300 interacting inhibitor of differentiation 1
  euchromatic histone lysine methyltransferase 1
  eukaryotic translation initiation factor 2 alpha kinase 1
  eukaryotic translation initiation factor 3 subunit B
  exosome component 6
  exportin 1
  extended synaptotagmin 1
  ezrin
  far upstream element binding protein 1
  F-box and WD repeat domain containing 11
  F-box protein 22
  F-box protein 31
  forkhead box O4
  G protein nucleolar 3
  G protein nucleolar 3 like
  G3BP stress granule assembly factor 2
  GLIS family zinc finger 2
  glycine C-acetyltransferase
  golgin, RAB6 interacting
  H2B clustered histone 11
  H2B clustered histone 21
  H3.4 histone
  H4 histone 16
  heat shock protein 90 beta family member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  hes related family bHLH transcription factor with YRPW motif 1
  heterogeneous nuclear ribonucleoprotein M
  HEXIM P-TEFb complex subunit 1
  high mobility group AT-hook 2
  histone deacetylase 3
  homeodomain interacting protein kinase 2
  hornerin
  immediate early response 2
  immediate early response 3
  importin 7
  insulin like growth factor 2 mRNA binding protein 3
  iodotyrosine deiodinase
  itchy E3 ubiquitin protein ligase
  junction mediating and regulatory protein, p53 cofactor
  junction-mediating and regulatory protein
  karyopherin subunit alpha 6
  large tumor suppressor kinase 1
  large tumor suppressor kinase 2
  leucine zipper tumor suppressor 2
  lysine acetyltransferase 2B
  lysine acetyltransferase 5
  MAGE family member D2
  MAK16 homolog
  makorin ring finger protein 3
  MAPK activated protein kinase 2
  maternal embryonic leucine zipper kinase
  MDM2 binding protein
  MDM2 proto-oncogene
  MDM4 regulator of p53
  mediator complex subunit 1
  mediator of DNA damage checkpoint 1
  membrane associated ring-CH-type finger 7
  metadherin
  metastasis associated 1
  microtubule associated protein 1 light chain 3 alpha
  MRE11 homolog, double strand break repair nuclease
  musashi RNA binding protein 2
  MYC proto-oncogene, bHLH transcription factor
  MYD88 innate immune signal transduction adaptor
  myeloid derived growth factor
  myosin light chain 6B
  N-acetyltransferase 10
  NADH:ubiquinone oxidoreductase core subunit S1
  nascent polypeptide associated complex subunit alpha
  NEDD4 E3 ubiquitin protein ligase
  nemo like kinase
  nerve growth factor receptor
  nibrin
  NIMA related kinase 9
  NME/NM23 nucleoside diphosphate kinase 2
  NOC2 like nucleolar associated transcriptional repressor
  NOP53 ribosome biogenesis factor
  notch receptor 1
  notch receptor 4
  nuclear casein kinase and cyclin dependent kinase substrate 1
  nuclear pore complex interacting protein family member B3
  nuclear receptor subfamily 0 group B member 2
  nucleolar and coiled-body phosphoprotein 1
  nucleolin
  nucleophosmin 1
  NUMB endocytic adaptor protein
  oxoglutarate dehydrogenase
  oxoglutarate dehydrogenase L
  p21 (RAC1) activated kinase 4
  p21 (RAC1) activated kinase 6
  PAK1 interacting protein 1
  PBX homeobox 1
  PBX homeobox interacting protein 1
  PDS5 cohesin associated factor A
  PDZ and LIM domain 7
  peptidylprolyl isomerase B
  period circadian regulator 2
  peroxisome proliferator activated receptor delta
  peroxisome proliferator activated receptor gamma
  peter pan homolog
  PHD finger protein 7
  phosphatase, orphan 1
  phosphodiesterase 4D
  phosphoglycerate mutase 1
  phosphoglycerate mutase 2
  Pim-1 proto-oncogene, serine/threonine kinase
  platelet derived growth factor subunit B
  pleckstrin homology like domain family B member 3
  PML nuclear body scaffold
  polo like kinase 1
  polypyrimidine tract binding protein 1
  PR/SET domain 2
  praja ring finger ubiquitin ligase 1
  programmed cell death 5
  proliferating cell nuclear antigen
  proliferation-associated 2G4
  proteasome 20S subunit alpha 3
  proteasome 20S subunit alpha 7
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 6
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 10
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 4
  proteasome activator subunit 3
  protection of telomeres 1
  protein inhibitor of activated STAT 1
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 regulatory subunit 10
  protein phosphatase 2 phosphatase activator
  protein phosphatase 2 regulatory subunit B'gamma
  protein phosphatase, Mg2+/Mn2+ dependent 1D
  protein tyrosine kinase 2
  pyrin and HIN domain family member 1
  pyruvate kinase M1/2
  RAB, member RAS oncogene family like 6
  RAB8A, member RAS oncogene family
  RAD23 homolog A, nucleotide excision repair protein
  RAD50 double strand break repair protein
  RAD54 homolog B
  RAN binding protein 1
  RAN binding protein 2
  Ras association domain family member 1
  Ras association domain family member 3
  Ras association domain family member 5
  Ras association domain family member 6
  RB binding protein 6, ubiquitin ligase
  RB binding protein 8, endonuclease
  RB transcriptional corepressor 1
  RB transcriptional corepressor like 2
  RE1 silencing transcription factor
  reactive intermediate imine deaminase A homolog
  RecQ like helicase
  RELA proto-oncogene, NF-kB subunit
  ret finger protein like 2
  retinoic acid receptor alpha
  retroelement silencing factor 1
  Rho GTPase activating protein 45
  ribonucleotide reductase catalytic subunit M1
  ribonucleotide reductase regulatory TP53 inducible subunit M2B
  ribosomal L1 domain containing 1
  ribosomal protein L10a
  ribosomal protein L11
  ribosomal protein L15
  ribosomal protein L22
  ribosomal protein L22 like 1
  ribosomal protein L23
  ribosomal protein L23a
  ribosomal protein L26
  ribosomal protein L36a
  ribosomal protein L37
  ribosomal protein L37a
  ribosomal protein L4
  ribosomal protein L5
  ribosomal protein L6
  ribosomal protein S11
  ribosomal protein S14
  ribosomal protein S15
  ribosomal protein S20
  ribosomal protein S23
  ribosomal protein S25
  ribosomal protein S26
  ribosomal protein S27
  ribosomal protein S27 like
  ribosomal protein S27a
  ribosomal protein S3
  ribosomal protein S5
  ribosomal protein S6
  ribosomal protein S6 kinase B1
  ribosomal protein S7
  ribosomal RNA processing 1
  ring finger and CHY zinc finger domain containing 1
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  ring finger and WD repeat domain 3
  ring finger protein 10
  ring finger protein 126
  ring finger protein 2
  ring finger protein 8
  ring finger protein, LIM domain interacting
  RING1 and YY1 binding protein
  RNA binding motif protein 38
  RuvB like AAA ATPase 2
  ryanodine receptor 2
  S100 calcium binding protein A1
  S100 calcium binding protein A2
  S100 calcium binding protein A4
  S100 calcium binding protein A6
  S100 calcium binding protein B
  sedoheptulokinase
  serine and arginine rich splicing factor 11
  serine/threonine kinase 11
  sestrin 2
  SET domain bifurcated histone lysine methyltransferase 1
  SET domain containing 7, histone lysine methyltransferase
  SET nuclear proto-oncogene
  SHANK associated RH domain interactor
  sirtuin 1
  sirtuin 2
  sirtuin 3
  sirtuin 6
  sirtuin 7
  SIVA1 apoptosis inducing factor
  SMAD specific E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 1
  SMG7 nonsense mediated mRNA decay factor
  snail family transcriptional repressor 1
  snail family transcriptional repressor 2
  sorbin and SH3 domain containing 2
  Sp1 transcription factor
  splicing factor 3b subunit 1
  splicing factor 3b subunit 3
  splicing factor proline and glutamine rich
  splicing regulatory glutamic acid and lysine rich protein 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRY-box transcription factor 4
  staphylococcal nuclease and tudor domain containing 1
  succinate dehydrogenase complex subunit C
  SUMO specific peptidase 3
  suppressor of variegation 3-9 homolog 1
  surfeit 2
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
  TATA-box binding protein
  TATA-box binding protein associated factor 1
  telomerase reverse transcriptase
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  titin-cap
  TNF receptor associated factor 5
  TP53 regulating kinase
  transcription termination factor 1
  transferrin receptor
  transformation related protein 53
  transformed mouse 3T3 cell double minute 4
  transforming growth factor beta regulated gene 1
  transforming growth factor beta regulator 1
  translocated promoter region, nuclear basket protein
  tripartite motif containing 13
  tripartite motif containing 25
  tripartite motif containing 27
  tripartite motif containing 28
  tripartite motif containing 32
  tripartite motif containing 4
  tripartite motif containing 46
  tripartite motif containing 47
  tripartite motif containing 59
  tripartite motif containing 67
  tripartite motif containing 9
  TSPY like 6
  tubulin alpha 1c
  tubulin beta 2A class IIa
  tubulin beta class I
  tuftelin interacting protein 11
  tumor protein p53
  tumor protein p53 inducible protein 3
  tumor protein p63
  tumor protein p73
  tumor protein, translationally-controlled 1
  tumor susceptibility 101
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 4
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin B
  ubiquitin C
  ubiquitin conjugating enzyme E2 A
  ubiquitin conjugating enzyme E2 B
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 E1
  ubiquitin conjugating enzyme E2 E2
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 G2
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 J2
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 N
  ubiquitin conjugating enzyme E2 O
  ubiquitin conjugating enzyme E2 Q1
  ubiquitin conjugating enzyme E2 Q2
  ubiquitin conjugating enzyme E2 R2
  ubiquitin conjugating enzyme E2 S
  ubiquitin conjugating enzyme E2 U
  ubiquitin conjugating enzyme E2 Z
  ubiquitin C-terminal hydrolase L1
  ubiquitin interaction motif containing 1
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 10
  ubiquitin specific peptidase 12
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 2
  ubiquitin specific peptidase 26
  ubiquitin specific peptidase 42
  ubiquitin specific peptidase 48
  ubiquitin specific peptidase 7
  ubiquitination factor E4B
  unc-119 lipid binding chaperone
  upstream binding transcription factor
  USO1 vesicle transport factor
  valosin containing protein
  valosin containing protein interacting protein 1
  vascular endothelial growth factor A
  vitamin D receptor
  WRN RecQ like helicase
  WT1 transcription factor
  WW domain containing oxidoreductase
  X antigen family member 1A
  X-box binding protein 1
  XPC complex subunit, DNA damage recognition and repair factor
  YY1 associated factor 2
  YY1 associated protein 1
  YY1 transcription factor
  zinc finger protein 133
  zinc finger protein 274
  zinc finger protein 318
  zinc finger protein 420
  zinc finger protein 550
  zinc finger protein 668
  zinc finger protein 764

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.